Dysregulation of MicroRNAs in cancer

被引：118

作者：

Chen, Pai-Sheng ^{[3
,4
]}

Su, Jen-Liang ^{[1
,2
,5
]}

Hung, Mien-Chie ^{[6
]}

机构：

[1] China Med Univ, Grad Inst Canc Biol, Taichung, Taiwan

[2] Asia Univ, Dept Biotechnol, Taichung, Taiwan

[3] Natl Cheng Kung Univ, Dept Med Lab Sci & Biotechnol, Tainan 70101, Taiwan

[4] Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 70101, Taiwan

[5] China Med Univ Hosp, Ctr Mol Med, Taichung, Taiwan

[6] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2012年 / 19卷

基金：

美国国家卫生研究院;

关键词：

Cancer progression; miRNA biogenesis; miRNA dysregulation; EPITHELIAL-MESENCHYMAL TRANSITION; CHRONIC LYMPHOCYTIC-LEUKEMIA; BREAST-CANCER; DOWN-REGULATION; LET-7; MICRORNA; CELL-PROLIFERATION; GLIOBLASTOMA CELLS; HIGH EXPRESSION; TUMOR INVASION; TARGETING BCL2;

D O I：

10.1186/1423-0127-19-90

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are involved in multiple biological activities as well as disease progression including cancer. Interestingly, miRNAs could act as either tumor suppressors or oncogenes depending on the functions of their targets. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer, and there is mounting evidence demonstrating several misguided mechanisms that cause miRNA dysregulation. In this review, we summarize the key functions of miRNAs in cancer, especially those affecting tumor metastasis and drug resistance. Moreover, the mechanisms leading to dysregulation of miRNAs, including genomic abnormalities, DNA/histone modifications, transcriptional regulation, abnormal biogenesis, and interaction between miRNAs, are also discussed.

引用

页数：8

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