SREBP: a novel therapeutic target

被引：111
作者：
Xiao, Xu [1 ]
Song, Bao-Liang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China
来源：
ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2013年 / 45卷 / 01期
关键词：
SREBP; insulin; cAMP; vitamin A; miRNA; therapeutic target; ELEMENT-BINDING PROTEIN-1C; HMG-COA REDUCTASE; LIVER-X-RECEPTOR; FATTY-ACID SYNTHESIS; NECROSIS-FACTOR-ALPHA; CHOLESTEROL HOMEOSTASIS; ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; LIPID-METABOLISM; COPII PROTEINS;
D O I：
10.1093/abbs/gms112
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the biosynthesis of cholesterol, fatty acid, and triglyceride. They control the expression of crucial genes involved in lipogenesis and uptake. In this review, we summarize the processing of SREBPs and their regulation by insulin, cAMP, and vitamin A, and the relationship between miRNA and lipid metabolism. We also discuss the recent functional studies on SREBPs. These discoveries suggest that inhibition of SREBP can be a novel strategy to treat metabolic diseases, such as type II diabetes, insulin resistance, fatty liver, and atherosclerosis.
引用
收藏
页码：2 / 10
页数：9
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