Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

被引:202
作者
Prasad, Sandeo [1 ]
Sung, Bokyung [1 ]
Aggarwal, Bharat B. [1 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Cytokine Res Lab, Houston, TX 77030 USA
基金
美国国家卫生研究院;
关键词
Chronic disease; Aging; Inflammation; Diet; Lifestyle; NF-KAPPA-B; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; ACTIVATED RECEPTOR-GAMMA; WHOLE-GRAIN INTAKE; URSOLIC ACID; PROSTATE-CANCER; MULTIPLE-SCLEROSIS; PROLONGED ACTIVATION; MOLECULAR-MECHANISMS;
D O I
10.1016/j.ypmed.2011.11.011
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Most chronic diseases-such as cancer, cardiovascular disease (CVD), Alzheimer disease, Parkinson disease, arthritis, diabetes and obesity-are becoming leading causes of disability and death all over the world. Some of the most common causes of these age-associated chronic diseases are lack of physical activity, poor nutrition, tobacco use, and excessive alcohol consumption. All the risk factors linked to these chronic diseases have been shown to up-regulate inflammation. Therefore, downregulation of inflammation-associated risk factors could prevent or delay these age-associated diseases. Although modem science has developed several drugs for treating chronic diseases, most of these drugs are enormously expensive and are associated with serious side effects and morbidity. In this review, we present evidence on how chronic inflammation leads to age-associated chronic disease. Furthermore, we discuss diet and lifestyle as solutions for age-associated chronic disease. Published by Elsevier Inc.
引用
收藏
页码:S29 / S37
页数:9
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