Synthesis and antibacterial activity of a new series of 2,3,5,7-substituted-pyrido[2,3-d]pyrimidin-4(3H)-one derivatives

被引：7

作者：

Bheemanapalli, Lakshmi Narayana ^{[1
]}

Akkinepally, Raghuram Rao ^{[1
]}

Pamulaparthy, Shanthan Rao ^{[2
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci, Dept Pharmaceut Chem, Chandigarh 160014, India

[2] Indian Inst Chem Technol, Fluoroorgan Div, Hyderabad 500007, Andhra Pradesh, India

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 09期

关键词：

pyrido[2,3]pyrimidin-4(3H)-one; N-substituted nicotinamide; antibacterial activity; 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide; triethylorthopropionate;

D O I：

10.1248/cpb.56.1342

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new series of 2,3,5,7-substituted-pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were prepared from 2amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides. The key intermediate 2-amino-N,6-substituted phenyl-4-(trifluoromethyl or methyl)nicotinamides were synthesized from 2-bromo-N,6-disubstituted phenyl-4-(trifluoromethyl or methyl)nicotinamides as well as from ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) coupling of 2-amino-4,6-substituted nicotinic acid and substituted arylamines. All the synthesized compounds were screened for antibacterial activity against Gram +ve and Gram -ve bacteria. Compound 7c showed better antibacterial activity against Gram +ve and Gram -ve bacteria.

引用

页码：1342 / 1348

页数：7

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