Functional diversity of cancer-associated fibroblasts in modulating drug resistance

被引：65
作者：
Bu, Luke [1 ,2 ]
Baba, Hideo [1 ]
Yasuda, Tadahito [1 ,2 ]
Uchihara, Tomoyuki [1 ,2 ]
Ishimoto, Takatsugu [1 ,2 ]
机构：
[1] Kumamoto Univ, Grad Sch Med Sci, Dept Gastroenterol Surg, Kumamoto, Japan
[2] Kumamoto Univ, Int Res Ctr Med Sci IRCMS, Gastrointestinal Canc Biol, Kumamoto, Japan
来源：
CANCER SCIENCE | 2020年 / 111卷 / 10期
基金：
日本学术振兴会;
关键词：
cancer stemness; cancer-associated fibroblast; chemoresistance; immunotherapy; metabolic modulation; CARCINOMA-ASSOCIATED FIBROBLASTS; TUMOR-ASSOCIATED FIBROBLASTS; STEM-CELLS; TGF-BETA; COLORECTAL-CANCER; MESENCHYMAL TRANSITION; POOR-PROGNOSIS; BREAST-CANCER; CHEMORESISTANCE; PROMOTE;
D O I：
10.1111/cas.14578
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effectiveness of current chemotherapies for cancer is gradually progressing; however achieving a complete cure through chemotherapy is still difficult and has been the main goal in treatment of advanced cancer. Drug resistance is an issue in cancer therapy, therefore increasing numbers of investigations into drug resistance have focused on the characteristics of the cancer cells themselves. The interaction between the tumor microenvironment (TME) and cancer cells is also intimately involved in the development of drug resistance. Cancer-associated fibroblasts (CAFs) are a predominant component of the TME and affect tumor progression by secreting soluble factors. This review summarizes the most up-to-date knowledge of CAFs and drug resistance in cancer, with a focus on factors secreted from CAFs including proteins, cytokines, extracellular vesicles, and metabolites. A perspective on the potential role of anti-CAF therapies in overcoming CAF-induced drug resistance is also discussed.
引用
收藏
页码：3468 / 3477
页数：10
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