A complement a day keeps the Fox(p3) away

被引：20

作者：

Le Friec, Gaelle ^{[1
]}

Koehl, Joerg ^{[2
,3
,4
]}

Kemper, Claudia ^{[1
]}

机构：

[1] Kings Coll London, Guys Hosp, Med Res Council Ctr Transplantat, Div Transplantat Immunol & Mucosal Biol, London WC2R 2LS, England

[2] Med Univ Lubeck, Inst Syst Inflammat Res, D-23538 Lubeck, Germany

[3] Cincinnati Childrens Hosp Med Ctr, Div Cellular & Mol Immunol, Cincinnati, OH USA

[4] Univ Cincinnati, Coll Med, Cincinnati, OH USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 02期

基金：

英国医学研究理事会;

关键词：

DECAY-ACCELERATING FACTOR; IFN-GAMMA; C5A; IMMUNITY; CELLS;

D O I：

10.1038/ni.2515

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Signaling via the complement factors C3a and C5a regulates effector T cell responses. Evidence now links the absence of local complement activation with a default pathway that leads to the polarization of Foxp3(+) regulatory T cells.

引用

页码：110 / 112

页数：3

共 12 条

[1] The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction [J].

Bamberg, Claire E. ;

Mackay, Charles R. ;

Lee, Hyun ;

Zahra, David ;

Jackson, Jenny ;

Lim, Yun Si ;

Whitfeld, Peter L. ;

Craig, Stewart ;

Corsini, Erin ;

Lu, Bao ;

Gerard, Craig ;

Gerard, Norma P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (10) :7633-7644

[2]

Fischer MB, 1998, J IMMUNOL, V160, P2619

[3] A regulatory role for the C5a anaphylatoxin in, type 2 immunity in asthma [J].

Köhl, J ;

Baelder, R ;

Lewkowich, IP ;

Pandey, MK ;

Hawlisch, H ;

Wang, LH ;

Best, J ;

Herman, NS ;

Sproles, AA ;

Zwirner, J ;

Whitsett, JA ;

Gerard, C ;

Sfyroera, G ;

Lambris, JD ;

Wills-Karp, M .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (03) :783-796

[4] Decay accelerating factor can control T cell differentiation into IFN-γ-producing effector cells via regulating local C5a-induced IL-12 production [J].

Lalli, Peter N. ;

Strainic, Michael G. ;

Lin, Feng ;

Medof, M. Edward ;

Heeger, Peter S. .

JOURNAL OF IMMUNOLOGY, 2007, 179 (09) :5793-5802

[5] The CD46-Jagged1 interaction is critical for human TH1 immunity [J].

Le Friec, Gaelle ;

Sheppard, Devon ;

Whiteman, Pat ;

Karsten, Christian M. ;

Shamoun, Salley Al-Tilib ;

Laing, Adam ;

Bugeon, Laurence ;

Dallman, Margaret J. ;

Melchionna, Teresa ;

Chillakuri, Chandramouli ;

Smith, Richard A. ;

Drouet, Christian ;

Couzi, Lionel ;

Fremeaux-Bacchi, Veronique ;

Koehl, Joerg ;

Waddington, Simon N. ;

McDonnell, James M. ;

Baker, Alastair ;

Handford, Penny A. ;

Lea, Susan M. ;

Kemper, Claudia .

NATURE IMMUNOLOGY, 2012, 13 (12) :1213-+

[6] IFN-γ and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production [J].

Liu, Jinbo ;

Lin, Feng ;

Strainic, Michael G. ;

An, Fengqi ;

Miller, Robert H. ;

Altuntas, Cengiz Z. ;

Heeger, Peter S. ;

Tuohy, Vincent K. ;

Medof, M. Edward .

JOURNAL OF IMMUNOLOGY, 2008, 180 (09) :5882-5889

[7] The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo [J].

Liu, JN ;

Miwa, T ;

Hilliard, B ;

Chen, YH ;

Lambris, JD ;

Wells, AD ;

Song, WC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (04) :567-577

[8] Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection [J].

Pavlov, Vasile ;

Raedler, Hugo ;

Yuan, Shuguang ;

Leisman, Staci ;

Kwan, Wing-Hong ;

Lalli, Peter N. ;

Medof, M. Edward ;

Heeger, Peter S. .

JOURNAL OF IMMUNOLOGY, 2008, 181 (07) :4580-4589

[9] Complement: a key system for immune surveillance and homeostasis [J].

Ricklin, Daniel ;

Hajishengallis, George ;

Yang, Kun ;

Lambris, John D. .

NATURE IMMUNOLOGY, 2010, 11 (09) :785-797

[10] Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells [J].

Strainic, Michael G. ;

Liu, Jinbo ;

Huang, Danping ;

An, Fengqi ;

Lalli, Peter N. ;

Muqim, Nasima ;

Shapiro, Virginia S. ;

Dubyak, George R. ;

Heeger, Peter S. ;

Medof, M. Edward .

IMMUNITY, 2008, 28 (03) :425-435

← 1 2 →