Angiotensin-converting enzyme polymorphisms and risk of spontaneous deep intracranial hemorrhage in Taiwan

被引:20
作者
Chen, C. -M. [2 ]
Chen, Y. -C. [2 ]
Wu, Y. -R. [2 ]
Hu, F. -J. [1 ]
Lyu, R. -K. [2 ]
Chang, H. -S. [2 ]
Ro, L. -S. [2 ]
Hsu, W. -C. [2 ]
Chen, S. -T. [2 ]
Lee-Chen, G. -J. [1 ]
机构
[1] Natl Taiwan Normal Univ, Dept Life Sci, Taipei 11677, Taiwan
[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol, Taipei, Taiwan
关键词
angiotensin-converting enzyme; hypertension; polymorphism and disease association; spontaneous deep intracranial hemorrhage;
D O I
10.1111/j.1468-1331.2008.02294.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and purpose: This study examines whether angiotensin-converting enzyme (ACE) gene polymorphisms are associated with the risk of spontaneous deep intracerebral hemorrhage (SDICH) in Taiwan using a case-control study. Methods: Totally, 217 SDICH patients and 283 controls were recruited. Associations of ACE A-240T and ACE I/D polymorphisms with SDICH were examined under the additive model and adjusted for gender, age, body mass index, total cholesterol level, smoking history, alcohol use, hypertension, and use of ACE inhibitors. Results: Hypertension, diabetes mellitus, family history of spontaneous intracerebral hemorrhage (SICH), and low cholesterol level increase risk of female SDICH, whereas hypertension, alcohol use, smoking history, family history of SICH, and low cholesterol level are an important risk factor for male SDICH. After adjusting for covariates, only haplotype ACE T-D (OR = 2.7, 95% CI, 1.1-6.5, P = 0.02) was associated with female SDICH. Conclusions: This study demonstrates that environmental risk factors play a major role and ACE polymorphisms play a minor role in contributing risk of SDICH in Taiwan.
引用
收藏
页码:1206 / 1211
页数:6
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