Programming of cardiovascular disease across the life-course

被引：45

作者：

Blackmore, Heather L. ^{[1
,2
]}

Ozanne, Susan E.

机构：

[1] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England

[2] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, MRC Metab Dis Unit, Cambridge CB2 0QQ, England

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 83卷

关键词：

Developmental programming; Developmental Origins of Health and Disease; Cardiovascular disease; MATERNAL PROTEIN RESTRICTION; CORONARY-HEART-DISEASE; HIGH-FAT DIET; SYSTOLIC BLOOD-PRESSURE; BODY-MASS INDEX; INTRAUTERINE GROWTH RESTRICTION; ACCELERATED POSTNATAL-GROWTH; GESTATIONAL WEIGHT-GAIN; PRENATAL EXPOSURE; DUTCH FAMINE;

D O I：

10.1016/j.yjmcc.2014.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality, affecting both developed and developing countries. Whilst it is well recognized that our risk of CVD can be determined by the interaction between our genetics and lifestyle, this only partly explains the variability at the population level. Based on these well-known risk factors, for many years, intervention and primary prevention strategies have focused on modifying lifestyle factors in adulthood. However, research shows that our risk of CVD can be pre-determined by our early life environment and this area of research is known as the Developmental Origins of Health and Disease. The aim of this review is to evaluate our current understanding of mechanisms underlying the programming of CVD. This article is part of a special issue entitled CV Aging. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：122 / 130

页数：9

共 132 条

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