Spectro-electrochemical and DFT study of tenoxicam metabolites formed by electrochemical oxidation

被引：6

作者：

Ramirez-Silva, M. T. ^{[1
]}

Guzman-Hernandez, D. S. ^{[1
]}

Galano, A. ^{[1
]}

Rojas-Hernandez, A. ^{[1
]}

Corona-Avendano, S. ^{[2
]}

Romero-Romo, M. ^{[2
]}

Palomar-Pardave, M. ^{[2
]}

机构：

[1] Univ Autonoma Metropolitana Iztapalapa, Dept Quim, Mexico City 09340, DF, Mexico

[2] Univ Autonoma Metropolitana Azcapotzalco, Dept Mat, Mexico City 02200, DF, Mexico

来源：

ELECTROCHIMICA ACTA | 2013年 / 111卷

关键词：

Tenoxicam; Oxidation products; Electrochemistry; UV-vis spectra; DFT; Chromatography; ALPHA-1-PROTEINASE INHIBITOR; LEUKOCYTE PEROXIDASES; INVOLVEMENT; PIROXICAM;

D O I：

10.1016/j.electacta.2013.07.191

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

From experimental (spectro-electrochemical) and theoretical (DFT) studies, the mechanisms of tenoxicam deprotonation and electrochemical oxidation were assessed. From these studies, new insights on the nature of the ampholitic species involved during tenoxicam's deprotonation in aqueous solution are presented; see scheme A. Moreover, it is shown that, after the analysis of two different reaction schemes that involve up to 10 different molecules and 12 reaction paths, the electrochemical oxidation of tenoxicam, yields two non-electroactive products that are predominately formed by its fragmentation, after the loss of two electrons. The nature of these fragments was further confirmed by a chromatography study. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：314 / 323

页数：10

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