Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems

被引：47

作者：

Salas, Isabel H. ^{[1
,2
]}

De Strooper, Bart ^{[1
,2
,3
]}

机构：

[1] VIB Ctr Brain & Dis Res, Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Neurosci, Leuven, Belgium

[3] ION UCL, UK Dementia Res Inst, DRI UK, London, England

来源：

NEUROCHEMICAL RESEARCH | 2019年 / 44卷 / 06期

关键词：

Alzheimer's disease; Diabetes; Dementia; Amyloid; Insulin; Glycemia; Metabolic stress; Cognition; HIGH-FAT DIET; MILD COGNITIVE IMPAIRMENT; INSULIN-DEGRADING ENZYME; TRANSGENIC MOUSE MODEL; BRAIN INSULIN; RISK-FACTORS; INTRANASAL INSULIN; VASCULAR DEMENTIA; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;

D O I：

10.1007/s11064-018-2690-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Type 2 diabetes mellitus is associated with an increased risk to develop Alzheimer disease, however, the underlying mechanisms for this association are still unclear. In this review we will provide a critical overview of the major findings coming from clinical studies and animal models.

引用

页码：1271 / 1278

页数：8

共 97 条

[1] Diabetes, Alzheimer disease, and vascular dementia A population-based neuropathologic study [J].

Ahtiluoto, S. ;

Polvikoski, T. ;

Peltonen, M. ;

Solomon, A. ;

Tuomilehto, J. ;

Winblad, B. ;

Sulkava, R. ;

Kivipelto, M. .

NEUROLOGY, 2010, 75 (13) :1195-1202

[2] Diabetes mellitus and Alzheimer's disease: shared pathology and treatment? [J].

Akter, Kawser ;

Lanza, Emily A. ;

Martin, Stephen A. ;

Myronyuk, Natalie ;

Rua, Melanie ;

Raffa, Robert B. .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2011, 71 (03) :365-376

[3] Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity [J].

Alberti, K. G. M. M. ;

Eckel, Robert H. ;

Grundy, Scott M. ;

Zimmet, Paul Z. ;

Cleeman, James I. ;

Donato, Karen A. ;

Fruchart, Jean-Charles ;

James, W. Philip T. ;

Loria, Catherine M. ;

Smith, Sidney C., Jr. .

CIRCULATION, 2009, 120 (16) :1640-1645

[4] High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice [J].

Arnold, Steven E. ;

Lucki, Irwin ;

Brookshire, Bethany R. ;

Carlson, Gregory C. ;

Browne, Caroline A. ;

Kazi, Hala ;

Bang, Sookhee ;

Choi, Bo-Ran ;

Chen, Yong ;

McMullen, Mary F. ;

Kim, Sangwon F. .

NEUROBIOLOGY OF DISEASE, 2014, 67 :79-87

[5] Intranasal insulin in Alzheimer's dementia or mild cognitive impairment: a systematic review [J].

Avgerinos, Konstantinos Ioannis ;

Kalaitzidis, Grigorios ;

Malli, Antonia ;

Kalaitzoglou, Dimitrios ;

Myserlis, Pavlos Gr. ;

Lioutas, Vasileios-Arsenios .

JOURNAL OF NEUROLOGY, 2018, 265 (07) :1497-1510

[6]

Avila Jesus, 2012, Int J Alzheimers Dis, V2012, P578373, DOI 10.1155/2012/578373

[7] Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes [J].

Baker, Laura D. ;

Cross, Donna J. ;

Minoshima, Satoshi ;

Belongia, Dana ;

Watson, Stennis ;

Craft, Suzanne .

ARCHIVES OF NEUROLOGY, 2011, 68 (01) :51-57

[8] Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs [J].

Balbaa, Mahmoud ;

Abdulmalek, Shaymaa A. ;

Khalil, Sofia .

PLOS ONE, 2017, 12 (05)

[9] Selective, physiological transport of insulin across the blood-brain barrier: Novel demonstration by species-specific radioimmunoassays [J].

Banks, WA ;

Jaspan, JB ;

Kastin, AJ .

PEPTIDES, 1997, 18 (08) :1257-1262

[10] Insulin in the brain: There and back again [J].

Banks, William A. ;

Owen, Joshua B. ;

Erickson, Michelle A. .

PHARMACOLOGY & THERAPEUTICS, 2012, 136 (01) :82-93

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