Human B-cell memory is shaped by age- and tissue-specific T-independent and GC-dependent events

被引：50

作者：

Aranburu, Alaitz ^{[1
]}

Mortari, Eva Piano ^{[1
]}

Baban, Anwar ^{[2
]}

Giorda, Ezio ^{[1
]}

Cascioli, Simona ^{[1
]}

Marcellini, Valentina ^{[1
]}

Scarsella, Marco ^{[1
]}

Ceccarelli, Sara ^{[1
]}

Corbelli, Sandro ^{[3
]}

Cantarutti, Nicoletta ^{[2
]}

De Vito, Rita ^{[4
]}

Inserra, Alessandro ^{[5
]}

Nicolosi, Luciana ^{[6
]}

Lanfranchi, Arnalda ^{[7
]}

Porta, Fulvio ^{[7
]}

Cancrini, Caterina ^{[8
,9
]}

Finocchi, Andrea ^{[8
,9
]}

Carsetti, Rita ^{[1
,10
]}

机构：

[1] Osped Pediatrico Bambino Gesu IRCSS, Immunol Res Area, Cell Physiopathol Unit B, Rome, Italy

[2] Bambino Gesu Children Hosp, Med & Surg Dept Pediat Cardiol, Rome, Italy

[3] Bambino Gesu Childrens Hosp IRCCS, Core Facil, Rome, Italy

[4] Bambino Gesu Childrens Hosp IRCCS, Div Pathol, Rome, Italy

[5] Bambino Gesu Childrens Hosp IRCCS, Pediat Gen & Thorac Surg Unit, Rome, Italy

[6] Bambino Gesu Childrens Hosp IRCCS, Dept Pediat, Rome, Italy

[7] Univ Brescia, Dept Pediat, Brescia, Italy

[8] Bambino Gesu Children Hosp, Univ Dept Pediat, DPUO, Rome, Italy

[9] Univ Tor Vergata, Sch Med, Rome, Italy

[10] Bambino Gesu Childrens Hosp IRCCS, Dept Oncohematol, Diagnost Immunol Unit, Rome, Italy

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2017年 / 47卷 / 02期

关键词：

Antibodies; B cells; B cell development; Immunoglobulins; Innate immunity; VARIABLE REGION GENES; IGM MEMORY; SOMATIC HYPERMUTATION; HUMAN SPLEEN; V-H; IMMUNODEFICIENCY; DIFFERENTIATION; GENERATION; ANTIBODIES; MUTATIONS;

D O I：

10.1002/eji.201646642

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Switched and IgM memory B cells execute different and noninterchangeable functions. We studied memory B cells in children of different ages, in peripheral blood and spleen and compared them with those of children born asplenic or unable to build germinal centers. We show that, whereas switched memory B cells are mostly generated in the germinal centers at all ages, IgM memory B cells can be distinct in three types with different developmental history. Innate IgM memory B cells, the largest pool in infants, are generated in the spleen by a germinal center-independent mechanism. With age, if the spleen is present and germinal centers are functional, innate IgM memory B cells are remodelled and accumulate somatic mutations. The third type of IgM memory B cell is a by-product of the germinal center reaction. Our data suggest that the B-cell memory developmental program is implemented during the first 5-6 years of life.

引用

页码：327 / 344

页数：18

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