Sex Differences in Clinical Characteristics, Hospital Management Practices, and In-Hospital Outcomes in Patients Hospitalized in a Vietnamese Hospital with a First Acute Myocardial Infarction

被引:9
作者
Nguyen, Hoa L. [1 ,2 ]
Duc Anh Ha [3 ]
Dat Tuan Phan [4 ]
Quang Ngoc Nguyen [4 ]
Viet Lan Nguyen [4 ]
Nguyen Hanh Nguyen [1 ]
Ha Nguyen [1 ]
Goldberg, Robert J. [5 ]
机构
[1] Inst Populat Hlth & Dev, Hanoi, Vietnam
[2] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
[3] Minist Hlth, Hanoi, Vietnam
[4] Viet Nam Natl Heart Inst, Hanoi, Vietnam
[5] Univ Massachusetts, Sch Med, Dept Quantitat Hlth Sci, Worcester, MA USA
关键词
ACUTE-CORONARY-SYNDROME; GENDER-DIFFERENCES; EARLY MORTALITY; HEART-DISEASE; ST ELEVATION; WOMEN; REGISTRY; MEN; SURVIVAL; TRENDS;
D O I
10.1371/journal.pone.0095631
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Cardiovascular disease is one of the leading causes of morbidity and mortality in Vietnam. We conducted a pilot study of Hanoi residents hospitalized with acute myocardial infarction (AMI) at the Vietnam National Heart Institute in Hanoi. The objectives of this observational study were to examine sex differences in clinical characteristics, hospital management, in-hospital clinical complications, and mortality in patients hospitalized with an initial AMI. Methods: The study population consisted of 302 Hanoi residents hospitalized with a first AMI at the largest tertiary care medical center in Hanoi in 2010. Results: The average age of study patients was 66 years and one third were women. Women were older (70 vs. 64 years) and were more likely than men to have had hyperlipidemia previously diagnosed (10% vs. 2%). During hospitalization, women were less likely to have undergone percutaneous coronary intervention (PCI) compared with men (57% vs. 74%), and women were more likely to have developed heart failure compared with men (19% vs. 10%). Women experienced higher in-hospital case-fatality rates (CFRs) than men (13% vs. 4%) and these differences were attenuated after adjustment for age and history of hyperlipidemia (OR: 2.64; 95% CI: 1.01, 6.89), and receipt of PCI during hospitalization (OR: 2.09; 95% CI: 0.77, 5.09). Conclusions: Our pilot data suggest that among patients hospitalized with a first AMI in Hanoi, women experienced higher in-hospital CFRs than men. Full-scale surveillance of all Hanoi residents hospitalized with AMI at all Hanoi medical centers is needed to confirm these findings. More targeted and timely educational and treatment approaches for women appear warranted.
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页数:6
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