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Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with men
被引:30
作者:
Hasselrot, Klara
[1
]
Saberg, Paer
[2
]
Hirbod, Taha
[1
]
Soderlund, Johan
[1
]
Ehnlund, Mariethe
[1
]
Bratt, Goeran
[2
]
Sandstrom, Eric
[2
]
Broliden, Kristina
[1
]
机构:
[1] Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Unit Infect Dis, S-17176 Stockholm, Sweden
[2] Soder Sjukhuset, Gay Mens Hlth Clin Venhalsan, Stockholm, Sweden
来源:
基金:
瑞典研究理事会;
关键词:
HIV-1;
IgA1;
men who have sex with men;
neutralization;
oral intercourse;
saliva;
IMMUNODEFICIENCY-VIRUS;
IMMUNOGLOBULIN-A;
HOMOSEXUAL MEN;
TRANSMISSION;
INFECTION;
INDIVIDUALS;
D O I:
10.1097/QAD.0b013e32831f924c
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Objective: To determine whether oral sexual exposure to HIV-1 (HIV) results ill HIV-neutralizing activity in saliva of uninfected men who have sex with infected men? Design: Saliva samples were collected from HIV lgG seronegative men (n = 25) whose male partners were HIV infected and from low-risk healthy controls (n = 22) and analyzed for HIV-neutralizing capacity. Methods: The presence of neutralizing activity in saliva was tested in a peripheral blood mononuclear cell-based assay using primary HIV isolates. Self-reporting questionnaires described the individuals' sexual behaviors and routes of possible HIV exposure. Results: Of 25 exposed, uninfected individuals (EUI), 21 reported receptive unprotected led oral intercourse, whereas three of the 25 reported unprotected anal receptive intercourse. Whole saliva from both EUI and low-risk healthy controls contained HIV-neutralizing activity. However, a significant difference was seen when analyzing the salivary IgA1 fraction: 13 of 25 EUI neutralized HIV, whereas none of the 22 controls had this capacity. The neutralizing capacity of the EUI males persisted during 2 years of follow-up. Conclusion: Unprotected oral sex evokes a salivary IgA1-mediated HIV-neutralizing response that persists over time (luring continuous exposure in uninfected male partners of infected men. (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
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页码:329 / 333
页数:5
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