Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with men

被引:30
作者
Hasselrot, Klara [1 ]
Saberg, Paer [2 ]
Hirbod, Taha [1 ]
Soderlund, Johan [1 ]
Ehnlund, Mariethe [1 ]
Bratt, Goeran [2 ]
Sandstrom, Eric [2 ]
Broliden, Kristina [1 ]
机构
[1] Karolinska Univ Hosp, Karolinska Inst, Ctr Mol Med, Dept Med,Unit Infect Dis, S-17176 Stockholm, Sweden
[2] Soder Sjukhuset, Gay Mens Hlth Clin Venhalsan, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
HIV-1; IgA1; men who have sex with men; neutralization; oral intercourse; saliva; IMMUNODEFICIENCY-VIRUS; IMMUNOGLOBULIN-A; HOMOSEXUAL MEN; TRANSMISSION; INFECTION; INDIVIDUALS;
D O I
10.1097/QAD.0b013e32831f924c
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Objective: To determine whether oral sexual exposure to HIV-1 (HIV) results ill HIV-neutralizing activity in saliva of uninfected men who have sex with infected men? Design: Saliva samples were collected from HIV lgG seronegative men (n = 25) whose male partners were HIV infected and from low-risk healthy controls (n = 22) and analyzed for HIV-neutralizing capacity. Methods: The presence of neutralizing activity in saliva was tested in a peripheral blood mononuclear cell-based assay using primary HIV isolates. Self-reporting questionnaires described the individuals' sexual behaviors and routes of possible HIV exposure. Results: Of 25 exposed, uninfected individuals (EUI), 21 reported receptive unprotected led oral intercourse, whereas three of the 25 reported unprotected anal receptive intercourse. Whole saliva from both EUI and low-risk healthy controls contained HIV-neutralizing activity. However, a significant difference was seen when analyzing the salivary IgA1 fraction: 13 of 25 EUI neutralized HIV, whereas none of the 22 controls had this capacity. The neutralizing capacity of the EUI males persisted during 2 years of follow-up. Conclusion: Unprotected oral sex evokes a salivary IgA1-mediated HIV-neutralizing response that persists over time (luring continuous exposure in uninfected male partners of infected men. (c) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins
引用
收藏
页码:329 / 333
页数:5
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