Use of domperidone in the treatment of canine visceral leishmaniasis: A clinical trial

被引:56
作者
Gomez-Ochoa, P. [1 ]
Castillo, J. A. [1 ]
Gascon, M. [1 ]
Zarate, J. J. [1 ]
Alvarez, F. [2 ]
Couto, C. G. [2 ]
机构
[1] Vet Fac Zaragoza, Dept Anim Pathol, Zaragoza 50013, Spain
[2] Ohio State Univ, Coll Vet Med, Dept Anim Pathol, Vet Teaching Hosp, Columbus, OH 43210 USA
关键词
Leishmaniasis; Immunomodulation; Domperidone; INFANTUM INFECTION; CELLULAR-IMMUNITY; PROLACTIN; DOGS; PROLIFERATION; PROTECTION; RESISTANCE; EFFICACY; HOST;
D O I
10.1016/j.tvjl.2007.09.014
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The aim of this study was to evaluate the effects of domperidone, a dopamine D2 receptor antagonist, in dogs naturally infected by Leishmania infantum. Ninety-eight dogs were treated with single-agent domperidone at I rng/kg twice a day orally for I month. Clinical, serological, biochemical and immunological examinations were conducted for the following 12 months. Domperidone was effective in controlling and reducing clinical signs and antibody titre. Significant decreases in reciprocal serum antibodies were seen in 74.3% of the dogs with mild clinical signs and 40% of the dogs became seronegative. In dogs with several clinical signs and high antibody titres, clinical improvement occurred in 86% of animals and the reciprocal serum antibody titres decreased in 38% of these dogs. A significant increase was noted in the immune cellular status, as measured by the leishmanin skin test and a lymphocyte proliferation assay. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:259 / 263
页数:5
相关论文
共 34 条
[1]   Chemotherapy of canine leishmaniosis [J].
Baneth, G ;
Shaw, SE .
VETERINARY PARASITOLOGY, 2002, 106 (04) :315-324
[2]  
Berczi I, 2000, ANN NY ACAD SCI, V917, P248
[3]   Use of a Leishmania skin test in the detection of canine Leishmania-specific cellular immunity [J].
Cardoso, L ;
Neto, F ;
Sousa, JC ;
Rodrigues, M ;
Cabral, M .
VETERINARY PARASITOLOGY, 1998, 79 (03) :213-220
[4]  
Ciaramella P, 2003, COMP CONT EDUC PRACT, V25, P358
[5]  
CIARAMELLA P, 2003, COMPENDIUM CONTINUIN, V5, P307
[6]   Prolactin reference range and pulsatility in male dogs [J].
Corrada, Yanina ;
Rimoldi, Isabel ;
Arreseigor, Susana ;
Marecco, Gonzalo ;
Gobello, Cristina .
THERIOGENOLOGY, 2006, 66 (6-7) :1599-1602
[7]   Low infectiousness of a wildlife host of Leishmania infantum:: the crab-eating fox is not important for transmission [J].
Courtenay, O ;
Quinnell, RJ ;
Garcez, LM ;
Dye, C .
PARASITOLOGY, 2002, 125 :407-414
[8]  
DACOSTAVAL AP, 2007, VET J
[9]   Practical guide for the treatment of leishmaniasis [J].
Davidson, RN .
DRUGS, 1998, 56 (06) :1009-1018
[10]   PROLACTIN PROTECTION AGAINST LETHAL EFFECTS OF SALMONELLA-TYPHIMURIUM [J].
DICARLO, R ;
MELI, R ;
GALDIERO, M ;
NUZZO, I ;
BENTIVOGLIO, C ;
CARRATELLI, CR .
LIFE SCIENCES, 1993, 53 (12) :981-989