Synthesis and characterization of novel 1,2,3-triazole-linked theophylline and coumarin s-triazines

被引：0

作者：

Joshi, Penny ^{[1
,2
]}

Tripathi, Mohit ^{[1
]}

Rawat, Diwan S. ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Kumaun Univ, Dept Chem, Naini Tal 263001, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2014年 / 53卷 / 03期

关键词：

s-Triazine; dendrimer; triazole; theophylline; coumarin; VITRO ANTIMALARIAL ACTIVITY; IMPROVED IN-VITRO; ANTIBACTERIAL ACTIVITY; DRUG-DELIVERY; DERIVATIVES; HYBRIDS; CYTOTOXICITY; DENDRIMERS; ANALOGS; DESIGN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel s-triazine-1,2,3-triazole-theophylline and s-triazine-1,2,3-triazole-coumarin generation-0 dendrimers has been synthesized and characterized by FT-IR, H-1 and C-13 NMR, and mass-spectral methods. Some 'selected compounds have been evaluated for antibacterial and antifungal activity against a variety of strains and for anti-cancer activity against 60 human cancer cell lines.

引用

页码：311 / 318

页数：8

共 42 条

[11]

CHARLES BG, 1979, MICROBIOS LETT, V10, P143

[12] Novel Small-Molecule Inhibitors of Hepatitis C Virus Entry Block Viral Spread and Promote Viral Clearance in Cell Culture [J].

Coburn, Glen A. ;

Fisch, Danielle N. ;

Moorji, Sameer M. ;

de Muys, Jean-Marc ;

Murga, Jose D. ;

Paul, Dorothy ;

Provoncha, Kathleen P. ;

Rotshteyn, Yakov ;

Han, Amy Q. ;

Qian, Dapeng ;

Maddon, Paul J. ;

Olson, William C. .

PLOS ONE, 2012, 7 (04)

[13] Design and Synthesis of Some New Theophylline Derivatives with Bronchodilator and Antibacterial Activities [J].

Hayallah, Alaa M. ;

Elgaher, Walid A. ;

Salem, Ola I. ;

Alim, Abdel Alim M. Abdel .

ARCHIVES OF PHARMACAL RESEARCH, 2011, 34 (01) :3-21

[14] A new series of estrogen receptor modulators that display selectivity for estrogen receptor β [J].

Henke, BR ;

Consler, TG ;

Go, N ;

Hale, RL ;

Hohman, DR ;

Jones, SA ;

Lu, AT ;

Moore, LB ;

Moore, JT ;

Orband-Miller, LA ;

Robinett, RG ;

Shearin, J ;

Spearing, PK ;

Stewart, EL ;

Turnbull, PS ;

Weaver, SL ;

Williams, SP ;

Wisely, GB ;

Lambert, MH .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (25) :5492-5505

[15] Phenoxypropoxybiguanides, prodrugs of DHFR-inhibiting diaminotriazine antimalarials [J].

Jensen, NP ;

Ager, AL ;

Bliss, RA ;

Canfield, CJ ;

Kotecka, BM ;

Rieckmann, KH ;

Terpinski, J ;

Jacobus, DP .

JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (23) :3925-3931

[16] Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives [J].

Kumar, Deepak ;

Raj, K. Kranthi ;

Bailey, MaiAnn ;

Alling, Torey ;

Parish, Tanya ;

Rawat, Diwan S. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (05) :1365-1369

[17] Synthesis and Antimalarial-Activity Evaluation of Tetraoxane-Triazine Hybrids and Spiro[piperidine-4,3′-tetraoxanes] [J].

Kumar, Nitin ;

Khan, Shabana I. ;

Rawat, Diwan S. .

HELVETICA CHIMICA ACTA, 2012, 95 (07) :1181-1197

[18] Synthesis and in vitro antimalarial activity of tetraoxane-amine/amide conjugates [J].

Kumar, Nitin ;

Khan, Shabana I. ;

Atheaya, Himanshu ;

Mamgain, Ritu ;

Rawat, Diwan S. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (07) :2816-2827

[19] Synthesis, antimalarial activity and cytotoxicity of substituted 3,6-diphenyl-[1,2,4,5]tetraoxanes [J].

Kumar, Nitin ;

Khan, Shabana I. ;

Beena ;

Rajalakshmi, G. ;

Kumaradhas, P. ;

Rawat, Diwan S. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (15) :5632-5638

[20] Iodine-catalyzed one-pot synthesis and antimalarial activity evaluation of symmetrically and asymmetrically substituted 3,6-diphenyl[1,2,4,5] tetraoxanes [J].

Kumar, Nitin ;

Khan, Shabana I. ;

Sharma, Mukul ;

Atheaya, Himanshu ;

Rawat, Diwan S. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) :1675-1677

← 1 2 3 4 5 →