Flow chemistry syntheses of natural products

被引:576
作者
Pastre, Julio C. [1 ]
Browne, Duncan L. [1 ]
Ley, Steven V. [1 ]
机构
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
基金
巴西圣保罗研究基金会; 英国工程与自然科学研究理事会;
关键词
ENABLING TECHNOLOGY; ORGANIC-SYNTHESIS; FLASH CHEMISTRY; SPONTANEOUS AUTOXIDATION; CHEMICAL-SYNTHESIS; GASEOUS AMMONIA; DRUG DISCOVERY; BOND FORMATION; SIALIC-ACID; REACTOR;
D O I
10.1039/c3cs60246j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The development and application of continuous flow chemistry methods for synthesis is a rapidly growing area of research. In particular, natural products provide demanding challenges to this developing technology. This review highlights successes in the area with an emphasis on new opportunities and technological advances.
引用
收藏
页码:8849 / 8869
页数:21
相关论文
共 132 条
[1]   The Development of a General Strategy for the Synthesis of Tyramine-Based Natural Products by Using Continuous Flow Techniques [J].
Achanta, Srinivas ;
Liautard, Virginie ;
Paugh, Robert ;
Organ, Michael G. .
CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (43) :12797-12800
[2]   Using Continuous Processes to Increase Production [J].
Anderson, Neal G. .
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2012, 16 (05) :852-869
[3]  
[Anonymous], 1979, CHINESE MED J-PEKING, V92, P811
[4]  
[Anonymous], 2008, Molecules that changed the world
[5]   Micro reactor and flow chemistry for industrial applications in drug discovery and development [J].
Baraldi, Patricia T. ;
Hessel, Volker .
GREEN PROCESSING AND SYNTHESIS, 2012, 1 (02) :149-167
[6]   Azide monoliths as convenient flow reactors for efficient Curtius rearrangement reactions [J].
Baumann, Marcus ;
Baxendale, Ian R. ;
Ley, Steven V. ;
Nikbin, Nikzad ;
Smith, Christopher D. .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (09) :1587-1593
[7]   A modular flow reactor for performing Curtius rearrangements as a continuous flow process [J].
Baumann, Marcus ;
Baxendale, Ian R. ;
Ley, Steven V. ;
Nikbin, Nikzad ;
Smith, Christopher D. ;
Tierney, Jason P. .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (09) :1577-1586
[8]   An Integrated Flow and Batch-Based Approach for the Synthesis of O-Methyl Siphonazole [J].
Baumann, Marcus ;
Baxendale, Ian R. ;
Brasholz, Malte ;
Hayward, John J. ;
Ley, Steven V. ;
Nikbin, Nikzad .
SYNLETT, 2011, (10) :1375-1380
[9]   SYNTHESIS OF HIGHLY SUBSTITUTED NITROPYRROLIDINES, NITROPYRROLIZINES AND NITROPYRROLES VIA MULTICOMPONENT-MULTISTEP SEQUENCES WITHIN A FLOW REACTOR [J].
Baumann, Marcus ;
Baxendale, Ian R. ;
Kirschning, Andreas ;
Ley, Steven V. ;
Wegner, Jens .
HETEROCYCLES, 2011, 82 (02) :1297-+
[10]   The flow synthesis of heterocycles for natural product and medicinal chemistry applications [J].
Baumann, Marcus ;
Baxendale, Ian R. ;
Ley, Steven V. .
MOLECULAR DIVERSITY, 2011, 15 (03) :613-630