A New Xanthone O-Glycoside from the Mangrove Endophytic Fungus Phomopsis sp.

被引：14

作者：

Huang, Zhongjing ^{[1
]}

Yang, Jianxiang ^{[2
]}

Lei, Fuhou ^{[1
]}

She, Zhigang ^{[3
]}

Lin, Yongcheng ^{[3
]}

机构：

[1] Guangxi Univ Nationalities, Coll Chem & Ecol Engn, Nanning 530006, Peoples R China

[2] Guilin Med Univ, Dept Chem & Engn, Guilin 541004, Peoples R China

[3] Sun Yat Sen Zhongshan Univ, Coll Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2013年 / 49卷 / 01期

基金：

中国国家自然科学基金;

关键词：

xanthone O-glycoside; mangrove endophytic fungus; structure elucidation; cytotoxic activity; SOUTH CHINA SEA; METABOLITES; ROOTS;

D O I：

10.1007/s10600-013-0497-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new xanthone O-glycoside, 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranosyl-1,4-dimethoxyxanthone (1), together with three known compounds, phomapyrone D (2), 2-methoxy-3,4-methylenedioxybenzophenone (3), and cyclo(D-6-Hyp-L-Phe) (4), was isolated from the mangrove endophytic fungus, Phomopsis sp. (ZH76). Their structures were determined by analysis of spectroscopic data. Compound 1 inhibited HEp-2 and HepG2 cells with IC50 values of 9 and 16 mu mol/mL, respectively.

引用

页码：27 / 30

页数：4