Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability

被引：126

作者：

Eltoukhy, Ahmed A. ^{[1
]}

Chen, Delai ^{[2
,3
]}

Alabi, Christopher A. ^{[2
]}

Langer, Robert ^{[1
,2
,4
,5
]}

Anderson, Daniel G. ^{[2
,4
,5
]}

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[2] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[3] Childrens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[4] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[5] MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 10期

基金：

美国国家卫生研究院;

关键词：

polymer; lipid; DNA; nanoparticle; gene therapy; PARALLEL SYNTHESIS; POLYMER LIBRARY; VECTORS; TRANSFECTION; DISCOVERY; THERAPY; CELLS;

D O I：

10.1002/adma.201204346

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：1487 / 1493

页数：7

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