Dynamic DNA methylation: a prime candidate for genomic metaplasticity and behavioral adaptation

被引:117
作者
Baker-Andresen, Danay [1 ]
Ratnu, Vikram S. [1 ]
Bredy, Timothy W. [1 ]
机构
[1] Univ Queensland, Psychiat Epigen Lab, Queensland Brain Inst, Brisbane, Qld 4072, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
DNA methylation; learning and memory; behavioral adaptation; metaplasticity; BDNF GENE-TRANSCRIPTION; L1; RETROTRANSPOSITION; EPIGENETIC REGULATION; CHROMATIN-STRUCTURE; MEMORY; EXPRESSION; PROMOTER; 5-HYDROXYMETHYLCYTOSINE; 5-METHYLCYTOSINE; DEMETHYLATION;
D O I
10.1016/j.tins.2012.09.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
DNA methylation was once considered to be a static epigenetic modification whose primary function was restricted to directing the development of cellular phenotype. However, it is now evident that the methylome is dynamically regulated across the lifespan: during development as a putative mechanism by which early experience leaves a lasting signature on the genome and during adulthood as a function of behavioral adaptation. Here, we propose that experience-dependent variations in DNA methylation, particularly within the context of learning and memory, represent a form of genomic metaplasticity that serves to prime the transcriptional response to later learning-related stimuli and neuronal reactivation.
引用
收藏
页码:3 / 13
页数:11
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