Cancer as a complex genetic trait: Tumor susceptibility in humans and mouse models

被引：109
作者：
Balmain, A [1 ]
机构：
[1] Univ Calif San Francisco, Dept Biochem & Biophys, Ctr Comprehens Canc, San Francisco, CA 94143 USA
来源：
CELL | 2002年 / 108卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(02)00622-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.
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收藏
页码：145 / 152
页数：8
相关论文
共 59 条
[1]  
Bala S, 2001, CANCER RES, V61, P6042
[2]   Cancer resistance genes in mice: models for the study of tumour modifiers [J].
Balmain, A ;
Nagase, H .
TRENDS IN GENETICS, 1998, 14 (04) :139-144
[3]   Carcinogenesis in mouse and human cells: parallels and paradoxes [J].
Balmain, A ;
Harris, CC .
CARCINOGENESIS, 2000, 21 (03) :371-377
[4]   EXPRESSION OF RECESSIVE ALLELES BY CHROMOSOMAL MECHANISMS IN RETINOBLASTOMA [J].
CAVENEE, WK ;
DRYJA, TP ;
PHILLIPS, RA ;
BENEDICT, WF ;
GODBOUT, R ;
GALLIE, BL ;
MURPHREE, AL ;
STRONG, LC ;
WHITE, RL .
NATURE, 1983, 305 (5937) :779-784
[5]   A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression [J].
Cohen, BA ;
Mitra, RD ;
Hughes, JD ;
Church, GM .
NATURE GENETICS, 2000, 26 (02) :183-186
[6]   Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis [J].
Cormier, RT ;
Hong, KH ;
Halberg, RB ;
Hawkins, TL ;
Richardson, P ;
Mulherkar, R ;
Dove, WF ;
Lander, ES .
NATURE GENETICS, 1997, 17 (01) :88-91
[7]   The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64 [J].
Cormier, RT ;
Bilger, A ;
Lillich, AJ ;
Halberg, RB ;
Hong, KH ;
Gould, KA ;
Borenstein, N ;
Lander, ES ;
Dove, WF .
ONCOGENE, 2000, 19 (28) :3182-3192
[8]   Experimental strategies for the genetic dissection of complex traits in animal models [J].
Darvasi, A .
NATURE GENETICS, 1998, 18 (01) :19-24
[9]   GENETIC IDENTIFICATION OF MOM-1, A MAJOR MODIFIER LOCUS AFFECTING MIN-INDUCED INTESTINAL NEOPLASIA IN THE MOUSE [J].
DIETRICH, WF ;
LANDER, ES ;
SMITH, JS ;
MOSER, AR ;
GOULD, KA ;
LUONGO, C ;
BORENSTEIN, N ;
DOVE, W .
CELL, 1993, 75 (04) :631-639
[10]  
Dunning AM, 1999, CANCER EPIDEM BIOMAR, V8, P843
123456