Detection of human papillomavirus types 6 and 11 in pubic and perianal hair from patients with genital warts

被引:46
作者
Boxman, ILA
Hogewoning, A
Mulder, LHC
Bavinck, JNB
ter Schegget, J
机构
[1] Acad Med Ctr, Dept Virol, NL-1105 AZ Amsterdam, Netherlands
[2] Leiden Univ, Ctr Med, Dept Dermatol, NL-2333 AA Leiden, Netherlands
关键词
D O I
10.1128/JCM.37.7.2270-2273.1999
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Genital human papillomavirus (HPV) types 6 and 11 are of clinical importance due to their role in the development of anogenital warts. A pilot study was performed to investigate whether DNAs from HPV types 6 and 11 are present in hairs plucked from the pubic and perianal regions and eyebrows of patients with genital warts at present and patients with a recent history of genital warts, Genital HPV DNA was detected in 9 of 25 (36%) pubic hair samples and in 11 of 32 (50%) perianal hair samples by the CPI/CPIIg PCR. After sequencing of 17 of 20 samples, HPV type 6 or 11 was detected in 6 of 25 (24%) hair samples from the pubis and 8 of 22 (36%) hair samples from the perianal region. These types were not detected in plucked eyebrow hairs. In contrast, the HPV types associated with epidermodysplasia verruciformis were detected in similar proportions (62%) in both samples of pubic and eyebrow hairs. Moreover, HPV type 6 and 11 DNAs were detected in pubic hairs plucked from mo patients mho had been successfully treated and who did not show any lesion at the time of hair collection; this finding is an argument that RPV DNA may persist in this region, The presence of genital HPV types in plucked pubic and perianal hair suggests that there is an endogenous reservoir for HPV which may play a role in the recurrences of genital warts.
引用
收藏
页码:2270 / 2273
页数:4
相关论文
共 12 条
[1]   Detection of new human papillomavirus sequences in skin lesions of a renal transplant recipient and characterization of one complete genome related to epidermodysplasia verruciformis-associated types [J].
Bens, G ;
Wieland, U ;
Hofmann, A ;
Höpfl, R ;
Pfister, H .
JOURNAL OF GENERAL VIROLOGY, 1998, 79 :779-787
[2]   NESTED PCR APPROACH FOR DETECTION AND TYPING OF EPIDERMODYSPLASIA VERRUCIFORMIS-ASSOCIATED HUMAN PAPILLOMAVIRUS TYPES IN CUTANEOUS CANCERS FROM RENAL-TRANSPLANT RECIPIENTS [J].
BERKHOUT, RJM ;
TIEBEN, LM ;
SMITS, HL ;
BAVINCK, JNB ;
VERMEER, BJ ;
TERSCHEGGET, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (03) :690-695
[3]  
BOLLEN LJM, 1998, THESIS U AMSTERDAM A
[4]   RAPID AND SIMPLE METHOD FOR PURIFICATION OF NUCLEIC-ACIDS [J].
BOOM, R ;
SOL, CJA ;
SALIMANS, MMM ;
JANSEN, CL ;
WERTHEIMVANDILLEN, PME ;
VANDERNOORDAA, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (03) :495-503
[5]   Detection of human papillomavirus DNA in plucked hairs from renal transplant recipients and healthy volunteers [J].
Boxman, ILA ;
Berkhout, RJM ;
Mulder, LHC ;
Wolkers, MC ;
Bavinck, JNB ;
Vermeer, BJ ;
terSchegget, J .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (05) :712-715
[6]  
BOXMAN ILA, 1997, 16 INT PAP C
[7]  
ORTH G, 1980, COLD SPRING HARBOR C, V7, P259
[8]   Role of HPV in cutaneous premalignant and malignant tumors [J].
Pfister, H ;
TerSchegget, J .
CLINICS IN DERMATOLOGY, 1997, 15 (03) :335-347
[9]   The primary target cells of the high-risk cottontail rabbit papillomavirus colocalize with hair follicle stem cells [J].
Schmitt, A ;
Rochat, A ;
Zeltner, R ;
Borenstein, L ;
Barrandon, Y ;
Wettstein, FO ;
Iftner, T .
JOURNAL OF VIROLOGY, 1996, 70 (03) :1912-1922
[10]   DETECTION AND TYPING OF HUMAN PAPILLOMAVIRUSES PRESENT IN FIXED AND STAINED ARCHIVAL CERVICAL SMEARS BY A CONSENSUS POLYMERASE CHAIN-REACTION AND DIRECT SEQUENCE-ANALYSIS ALLOW THE IDENTIFICATION OF A BROAD-SPECTRUM OF HUMAN PAPILLOMAVIRUS TYPES [J].
SMITS, HL ;
TIEBEN, LM ;
TJONGAHUNG, SP ;
JEBBINK, MF ;
MINNAAR, RP ;
JANSEN, CL ;
TERSCHEGGET, J .
JOURNAL OF GENERAL VIROLOGY, 1992, 73 :3263-3268