Reelin glycoprotein in autism and schizophrenia

被引：43

作者：

Fatemi, SH ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Psychiat, Minneapolis, MN 55455 USA

来源：

GABA IN AUTISM AND RELATED DISORDERS | 2005年 / 71卷

关键词：

D O I：

10.1016/S0074-7742(05)71008-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Reelin glycoprotein is a serine protease with important roles in embryogenesis and in adult life. Reelin mutations or deficiency of the protein product could cause abnormal cortical development and/or Reelin-induced signal transduction impairment in brain. Reelin abnormalities in several neuropsychiatric disorders, such as autism and schizophrenia, may provide mechanistic explanations for etiologies of these disorders.

引用

页码：179 / 187

页数：9

共 49 条

[1] Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients:: A preliminary report [J].

Abdolmaleky, HM ;

Cheng, KH ;

Russo, A ;

Smith, CL ;

Faraone, SV ;

Wilcox, M ;

Shafa, R ;

Glatt, SJ ;

Nguyen, G ;

Ponte, JF ;

Thiagalingam, S ;

Tsuang, MT .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 134B (01) :60-66

[2] Association analysis of polymorphic CGG repeat in 5′ UTR of the reelin and VLDLR genes with schizophrenia [J].

Akahane, A ;

Kunugi, H ;

Tanaka, H ;

Nanko, S .

SCHIZOPHRENIA RESEARCH, 2002, 58 (01) :37-41

[3] Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3β [J].

Beffert, U ;

Morfini, G ;

Bock, HH ;

Reyna, H ;

Brady, ST ;

Herz, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (51) :49958-49964

[4] Analysis of reelin as a candidate gene for autism [J].

Bonora, E ;

Beyer, KS ;

Lamb, JA ;

Parr, JR ;

Klauck, SM ;

Benner, A ;

Paolucci, M ;

Abbott, A ;

Ragoussis, I ;

Poustka, A ;

Bailey, AJ ;

Monaco, AP .

MOLECULAR PSYCHIATRY, 2003, 8 (10) :885-892

[5] Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation [J].

Carboni, G ;

Tueting, P ;

Tremolizzo, L ;

Sugaya, I ;

Davis, J ;

Costa, E ;

Guidotti, A .

NEUROPHARMACOLOGY, 2004, 46 (08) :1070-1081

[6] TIME OF ORIGIN OF CORRESPONDING CELL CLASSES IN CEREBRAL-CORTEX OF NORMAL AND REELER MUTANT MICE - AUTORADIOGRAPHIC ANALYSIS [J].

CAVINESS, VS ;

SIDMAN, RL .

JOURNAL OF COMPARATIVE NEUROLOGY, 1973, 148 (02) :141-151

[7] Identification of a single nucleotide polymorphism at the 5′ promoter region of human reelin gene and association study with schizophrenia [J].

Chen, ML ;

Chen, SY ;

Huang, CH ;

Chen, CH .

MOLECULAR PSYCHIATRY, 2002, 7 (05) :447-448

[8]

Costa Erminio, 2003, Mol Interv, V3, P220, DOI 10.1124/mi.3.4.220

[9] Reelin is a ligand for lipoprotein receptors [J].

D'Arcangelo, G ;

Homayouni, R ;

Keshvara, L ;

Rice, DS ;

Sheldon, M ;

Curran, T .

NEURON, 1999, 24 (02) :471-479

[10] A PROTEIN RELATED TO EXTRACELLULAR-MATRIX PROTEINS DELETED IN THE MOUSE MUTANT REELER [J].

DARCANGELO, G ;

MIAO, GG ;

CHEN, SC ;

SOARES, HD ;

MORGAN, JI ;

CURRAN, T .

NATURE, 1995, 374 (6524) :719-723

← 1 2 3 4 5 →