Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma

被引：41

作者：

Homburg, Ursula ^{[1
]}

Renz, Harald ^{[2
,3
]}

Timmer, Wolfgang

Hohlfeld, Jens M. ^{[4
]}

Seitz, Friedeborg ^{[5
]}

Lueer, Katrin ^{[4
]}

Mayer, Alexandra ^{[5
]}

Wacker, Anja ^{[6
]}

Schmidt, Oliver ^{[6
]}

Kuhlmann, Jens ^{[1
]}

Turowska, Agnieszka ^{[1
]}

Roller, Julia ^{[7
]}

Kutz, Klaus ^{[8
]}

Schlueter, Gerhard

Krug, Norbert ^{[4
]}

Garn, Holger ^{[2
,3
]}

机构：

[1] Sterna Biol GmbH, Marburg, Germany

[2] Univ Giessen, Univ Marburg, Fac Med, Inst Lab Med & Pathobiochem Mol Diagnost, Marburg, Germany

[3] Marburg Lung Ctr UGMLC, Marburg, Germany

[4] Fraunhofer Inst Toxicol & Expt Med, Dept Clin Airway Res, Hannover, Germany

[5] CRS Clin Res Serv Mannheim GmbH, Mannheim, Germany

[6] Engelhard Arzneimittel GmbH, Niederdorfelden, Germany

[7] Vectura GmbH, Gauting, Germany

[8] AccelPharm, Basel, Switzerland

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2015年 / 136卷 / 03期

关键词：

GATA-3-SPECIFIC DNAZYME; ACTIVATION; EXPRESSION; TOXICITY; EXPOSURE; HGD40;

D O I：

10.1016/j.jaci.2015.02.018

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：797 / +

页数：4

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