Successful hematopoietic cell transplantation in a patient with X-linked agammaglobulinemia and acute myeloid leukemia

被引：26

作者：

Abu-Arja, Rolla F. ^{[1
]}

Chernin, Leah R. ^{[2
]}

Abusin, Ghada ^{[3
]}

Auletta, Jeffery ^{[1
]}

Cabral, Linda ^{[4
]}

Egler, Rachel ^{[4
]}

Ochs, Hans D. ^{[5
,6
]}

Torgerson, Troy R.

Lopez-Guisa, Jesus ^{[5
,6
]}

Hostoffer, Robert W. ^{[2
]}

Tcheurekdjian, Haig ^{[2
]}

Cooke, Kenneth R. ^{[7
]}

机构：

[1] Nationwide Childrens Hosp, Pediat Blood & Marrow Transplant Program, Columbus, OH 43205 USA

[2] Case Western Reserve Univ, Allergy Immunol Associates Inc, Cleveland, OH 44106 USA

[3] Univ Iowa, Childrens Hosp, Pediat Bone Marrow Transplant Program, Iowa City, IA USA

[4] Rainbow Babies & Childrens Hosp, Pediat Bone Marrow Transplant, Case Med Ctr, Cleveland, OH 44106 USA

[5] Univ Washington, Seattle, WA 98195 USA

[6] Seattle Childrens Res Inst, Seattle, WA USA

[7] Johns Hopkins Univ, Pediat Blood & Marrow Transplant Sidney Kimmel Ca, Baltimore, MD USA

来源：

PEDIATRIC BLOOD & CANCER | 2015年 / 62卷 / 09期

关键词：

acute myeloid leukemia; stem cell transplantation; X-linked agammaglobulinemia; GENE; THERAPY; DISEASE; BTK;

D O I：

10.1002/pbc.25554

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency characterized by marked reduction in all classes of serum immunoglobulins and the near absence of mature CD19(+) B-cells. Although malignancy has been observed in patients with XLA, we present the first reported case of acute myeloid leukemia (AML) in a patient with XLA. We also demonstrate the complete correction of the XLA phenotype following allogeneic hematopoietic cell transplantation for treatment of the patient's leukemia. Pediatr Blood Cancer 2015;62:1674-1676. (c) 2015 Wiley Periodicals, Inc.

引用

页码：1674 / 1676

页数：3

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