Synthesis of a novel fused tricyclic heterocycle, pyrimido[5,4-e][1,4]thiazepine, and its derivatives

被引：6

作者：

Bazazan, Tahmineh ^{[1
]}

Bakavoli, Mehdi ^{[1
]}

Rahimizadeh, Mohammad ^{[1
]}

Eshghi, Hossein ^{[1
]}

Nikpour, Mohsen ^{[2
]}

机构：

[1] Ferdowsi Univ Mashhad, Dept Chem, Sch Sci, Mashhad 917751436, Iran

[2] Islamic Azad Univ, Dept Chem, Ahvaz Branch, Ahvaz 6134968875, Iran

来源：

HETEROCYCLIC COMMUNICATIONS | 2013年 / 19卷 / 06期

关键词：

5,4-e][1,4]benzothiazepines; nucleophilic substitution; secondary amines; 1,4-thiazepine;

D O I：

10.1515/hc-2013-0170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sequential treatment of 5-bromo-2,4-dichloro-6-(chloromethyl)pyrimidine with 2-aminothiophenol and secondary amines afforded a series of 2-[(5-bromo-2-chloro-6-aminopyrimidin-4-yl)methylthio]aniline derivatives. Reaction of the latter compounds with secondary amines in ethanol gave a family of new 5,7-diamino-5,11-dihydropyrimido[5,4-e][1,4]benzothiazepines.

引用

页码：401 / 404

页数：4

共 16 条

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