Cycloalkylation of C(sp3)-H Bond with Neighboring Carboxylic Acid as Traceless Activating Group

被引：26

作者：

Lv, Leiyang ^{[1
]}

Li, Zhiping ^{[1
]}

机构：

[1] Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 05期

基金：

美国国家科学基金会;

关键词：

DIRECTING GROUPS; FUNCTIONALIZATION; CONSTRUCTION; ARYLATION; STRATEGY; PHOTOREDOX; CATALYSIS;

D O I：

10.1021/acs.joc.6b03091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective functionalization of inert C(sp(3))-H bond is one of cutting-edge challenges in chemical synthesis. A novel strategy for selective C(sp(3))-H bond cydoalkylation is developed with neighboring carboxylic acid as a traceless activating group. Primary and secondary alkyl carboxylic acids undergo decarboxylation/alpha-C(sp(3))-H cleavage/cycloalkylation to give the five membered cyclization products, while tertiary adds undergo decarboxylation/ss-C(sp(3))-H cleavage/cycloalkylation to generate the six-membered cyclization products.

引用

页码：2689 / 2702

页数：14

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