Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints

被引:62
作者
Bookheimer, Susan Y. [1 ,2 ,3 ,4 ]
Renner, Brian A. [1 ,2 ,3 ,4 ]
Ekstrom, Arne [1 ,2 ,3 ,4 ]
Li, Zhaoping [1 ,2 ,3 ,4 ]
Henning, Susanne M. [1 ,2 ,3 ,4 ]
Brown, Jesse A. [1 ,2 ,3 ,4 ]
Jones, Mike [1 ,2 ,3 ,4 ]
Moody, Teena [1 ,2 ,3 ,4 ]
Small, Gary W. [1 ,2 ,3 ,4 ]
机构
[1] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Ctr Cognit Neurosci, Los Angeles, CA 90024 USA
[2] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Human Nutr, Los Angeles, CA 90024 USA
[4] Univ Calif Los Angeles, UCLA Longev Ctr, Los Angeles, CA 90024 USA
关键词
COGNITIVE FUNCTION; ALZHEIMER-DISEASE; BEHAVIORAL DEFICITS; OXIDATIVE STRESS; IMPROVES MEMORY; EPISODIC MEMORY; WORKING-MEMORY; DIETARY-INTAKE; MOUSE MODEL; VITAMIN-E;
D O I
10.1155/2013/946298
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare. Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice. We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures. Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks. Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention. Investigators and subjects were all blind to group membership. After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide. Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks. While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity.
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页数:14
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