Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults

被引:641
作者
Brook, RD
Brook, JR
Urch, B
Vincent, R
Rajagopalan, S
Silverman, F
机构
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] Univ Toronto, Toronto, ON, Canada
[3] Hlth Canada, Ottawa, ON K1A 0L2, Canada
[4] Environm Canada, Toronto, ON, Canada
关键词
vasculature; endothelin; endothelium; air pollution;
D O I
10.1161/01.CIR.0000013838.94747.64
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function. Methods and Results-Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of approximate to150 mug/m(3) of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (-0.09+/-0.15 mm versus +0.01+/-0.18 mm, P=0.03). There were no significant differences in FMD (+0.29+/-4.11% versus -0.03+/-6.63%, P=0.88), NMD (+3.87+/-5.43% versus +3.46+/-7.92%, P=0.83), or blood pressure responses between exposures. Conclusions-Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.
引用
收藏
页码:1534 / 1536
页数:3
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