A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

被引：215

作者：

Li, Chengming

Madsen, Jeppe

Armes, Steven P.

Lewis, Andrew L.

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Biocompatibles Ltd, Farnham GU9 8QL, Surrey, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期

关键词：

biomimetic synthesis; copolymers; gels; micelles; peptide-induced degradation;

D O I：

10.1002/anie.200600324

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3510 / 3513

页数：4