A new class of biochemically degradable, stimulus-responsive triblock copolymer gelators

被引：215
|
作者：
Li, Chengming
Madsen, Jeppe
Armes, Steven P.
Lewis, Andrew L.
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Biocompatibles Ltd, Farnham GU9 8QL, Surrey, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期
关键词：
biomimetic synthesis; copolymers; gels; micelles; peptide-induced degradation;
D O I：
10.1002/anie.200600324
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Graph Presented) To rub gel into the wound: A thermoresponsive ABA triblock copolymer gelator with A=N-isopropylacrylamide and B=2- (methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide-based initiator. This triblock copolymer forms free-standing peptide-degradable micellar gels under physiologically relevant conditions. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3510 / 3513
页数：4
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