Enhanced cell affinity of poly(L-lactide) film by immobilizing phosphonized chitosan

被引：6
|
作者：
Tian Ye [1 ]
Zhou Chang-ren [1 ]
Zeng Qing-Hui [1 ]
Yang Ju-Lin [1 ]
Han Feng-Xian [1 ]
Tian Jin-Huan [1 ]
机构：
[1] Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China
来源：
APPLIED SURFACE SCIENCE | 2008年 / 255卷 / 02期
关键词：
Poly(L-lactide); N-Methylene phosphonic chitosan; UV irradiation; Cell affinity;
D O I：
10.1016/j.apsusc.2008.06.073
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Graft polymerization of acrylic acid (AA) onto poly(L-lactide) (PLLA) film by UV irradiation was carried out to develop surfaces for N-methylene phosphonic chitosan (NMPC) immobilization. The properties of modified films were discussed by colorimetric method, attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), contact angles, atomic force microscopy (AFM) and osteoblast incubation. The results showed that AA solution concentration and irradiation time had effect on the graft carboxyl densities. Comparing the ATR-FTIR images, two new peaks at 1561 cm (1) and 1632 cm (1) proved that NMPC was immobilized on the film surface successfully. The water contact-angles were decreased from 90 +/- 5 degrees to 37 +/- 5 degrees after modification. The AFM images indicated that the surface of the combined film was rougher than that of untreated film. The grafted film provided an excellent substrate for the growth of osteoblast. (C) 2008 Published by Elsevier B.V.
引用
收藏
页码：446 / 448
页数：3
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