Analysis of Meiotic Segregation Pattern and Interchromosomal Effects in a Bull Heterozygous for a 3/16 Robertsonian Translocation

被引：8
作者：
Barasc, Harmonie [1 ]
Mouney-Bonnet, Nathalie [1 ]
Peigney, Clemence [1 ]
Calgaro, Anne [1 ]
Revel, Clemence [1 ]
Mary, Nicolas [1 ]
Ducos, Alain [1 ]
Pinton, Alain [1 ]
机构：
[1] Univ Toulouse, GenPhySE, INRA, ENVT, Castanet Tolosan, France
来源：
CYTOGENETIC AND GENOME RESEARCH | 2018年 / 156卷 / 04期
关键词：
Cattle; Interchromosomal effect; Robertsonian translocation; Sperm-FISH; LOW SPERM COUNTS; INFERTILE MEN; X-TRISOMY; CHROMOSOMAL REARRANGEMENTS; CYTOGENETIC INVESTIGATIONS; SYNAPTONEMAL COMPLEX; CATTLE; FISH; KARYOTYPE; SPERMATOZOA;
D O I：
10.1159/000494289
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Robertsonian translocations are the most frequent chromosomal rearrangements detected in cattle. Here, we report on the detection of a new Robertsonian translocation between chromosomes BTA3 and BTA16. This rob(3; 16) was dicentric, suggesting that its occurrence was recent. FISH analysis of decondensed sperm nuclei revealed a relatively low rate of unbalanced gametes produced by adjacent segregation (5.87%). In addition, and for the first time in bovines, a significant interchromosomal effect (ICE) was detected for 2 different autosomes: BTA17 (global disomy + nullisomy rate of 9%) and BTA20 (1.8%). These results suggest that ICE should be taken into consideration when assessing the putative effect of Robertsonian translocations on reproduction. (C) 2018 S. Karger AG, Basel
引用
收藏
页码：197 / 203
页数：7
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