Characterization of lymphocytic infiltrates in Helicobacter pylori-associated gastritis

被引:54
作者
Hatz, RA
Meimarakis, G
Bayerdorffer, E
Stolte, M
Kirchner, T
Enders, G
机构
[1] UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT INTERNAL MED 2,D-81377 MUNICH,GERMANY
[2] UNIV ERLANGEN NURNBERG,INST PATHOL,W-8520 ERLANGEN,GERMANY
[3] KLINIKUM BAYREUTH,INST PATHOL,BAYREUTH,GERMANY
关键词
chemokines; gastritis; Helicobacter pylori; intraepithelial; lamina propria; lymphocyte subsets;
D O I
10.3109/00365529609004870
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: This study evaluated the specific subset composition of lymphocytes present in Helicobacter pylori-associated gastritis (HAG), since reports so far have led to inconclusive and conflicting results. Methods: Endoscopic biopsy specimens from 56 patients were studied by quantitative immunohistochemistry using monoclonal antibodies against the lymphocyte markers CD3, CD22, CD4, CD8, CD45RO, CD103, TCR alpha/beta, and TCR gamma/delta. Lamina propria and intraepithelial compartments were evaluated separately. Grade, activity, and density of bacterial colonisation were assessed histologically and with Warthin-Starry stain. Results: Evaluation showed a significant increase in CD4+, CD45RO+, TCR alpha/beta+ activated lamina propria lymphocytes in HAG which correlated with grade and activity of gastritis and degree of bacterial colonisation, whereas subsets of intraepithelial lymphocytes did not change significantly. TCR gamma/delta+ T cells were not found to be increased in HAG. Conclusions: Selective expansion of CD4+, CD45RO+ memory-type T cells could reflect an antigen-specific and/or chemokine-mediated effect in HAG. Locally produced CC chemokines such as RANTES have been detected in HAG.
引用
收藏
页码:222 / 228
页数:7
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