A randomized double-blind controlled study of the efficacy of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy

被引:6
作者
Wang, Yanfen [3 ]
Jiang, Xi [2 ]
Pang, Lei [1 ]
Dong, Su [1 ]
Feng, Yanhua [1 ]
Prajapati, Sujan Surya [1 ]
Yuan, Changji [2 ]
Ma, Haichun [1 ]
机构
[1] Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun 130023, Jilin, Peoples R China
[2] Jilin Univ, Hosp 1, Ctr Canc, Changchun 130023, Jilin, Peoples R China
[3] Jilin Univ, Hosp 2, Dept Gastroenterol, Changchun 130023, Jilin, Peoples R China
关键词
Ketofol; ketamine; propofol; fentanyl; procedural sedation; abortion; KETAMINE-PROPOFOL; EMERGENCY-DEPARTMENT; PEDIATRIC-PATIENTS; COMBINATION; SEDATION; ANESTHESIA;
D O I
10.5897/AJPP12.049
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objectives of this study are to compare the effectiveness of different proportions of ketamine and propofol in ketamine-propofol single-syringe combination (ketofol), and to compare the effectiveness of ketofol with propofol-fentanyl and propofol alone in termination of pregnancy. Randomized, double-blind, controlled study of 100 female American Society of Anesthesiologists (ASA I or II) patients of age 18 to 40 years undergoing abortion was used. Patients were randomly divided into 5 groups of 20. Groups K21, K31, and K41 were given ketofol intravenously in the ratios of propofol: ketamine, 2: 1, 3: 1, and 4: 1, respectively in small aliquots; group PF was given 1.5 to 2 mg/kg propofol and 50 mcg fentanyl, whereas group P was given only 2 mg/kg propofol. Blood pressure, heart rate, oxygen saturation; surgery, anesthesia, sedation, recovery, and discharge times were recorded. There was significant difference ( P<0.05) in anesthesia, sedation, and discharge times. Group K21 had higher sedation, recovery, and discharge times than the other groups. All ketofol groups had high incidence of postoperative dizziness, whereas the non-ketofol groups had high incidence of intraoperative respiratory depression. Ketofol groups required less dosage of propofol than the non-ketofol groups with group P requiring the highest (3.5 +/- 0.6 mg/kg). Ketofol is as effective as propofol-fentanyl combination, especially in the ratios 3:1 and 4:1 (propofol: ketamine) for abortion.
引用
收藏
页码:2510 / 2514
页数:5
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