Antisense antibacterial compounds

被引：22
作者：
Pifer, Reed
Greenberg, David E.
机构：
[1] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA
[2] Univ Texas Southwestern Med Ctr Dallas, Dept Microbiol, Dallas, TX USA
来源：
TRANSLATIONAL RESEARCH | 2020年 / 223卷
关键词：
Antisense; Peptide-conjugated phosphorodiamidate morpholino oligomers; PPMOs; Antibiotics; Antibiotic resistance; PEPTIDE NUCLEIC-ACID; EXTERNAL GUIDE SEQUENCES; CELL-PENETRATING PEPTIDE; ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI RIBONUCLEASE; INFECTIOUS-DISEASE MORTALITY; DEGRADING RNA MOIETY; GENE-EXPRESSION; IN-VITRO; STAPHYLOCOCCUS-AUREUS;
D O I：
10.1016/j.trsl.2020.06.001
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Extensive antibiotic use combined with poor historical drug stewardship practices have created a medical crisis in which once treatable bacterial infections are now increasingly unmanageable. To combat this, new antibiotics will need to be developed and safeguarded. An emerging class of antibiotics based upon nuclease-stable antisense technologies has proven valuable in preclinical testing against a variety of bacterial pathogens. This review describes the current state of development of antisense-based antibiotics, the mechanisms thus far employed by these compounds, and possible future avenues of research.
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收藏
页码：89 / 106
页数：18
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