Pathophysiology of Parkinson's disease

被引:38
作者
Bonnet, AM [1 ]
Houeto, JL [1 ]
机构
[1] Hop La Pitie Salpetriere, Federat Neurol, F-75651 Paris 13, France
关键词
Parkinson's disease; pathophysiology;
D O I
10.1016/S0753-3322(99)80076-6
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Parkinson's disease is a progressive disease with selective dopaminergic neuronal loss. The pathophysiology is at present better understood with plurifactorial etiology, including genetic predisposition and environmental toxic factors. The mechanisms of cell death are based upon oxidative stress and apoptosis. The heterogeneity of dopaminergic neuronal loss leads to etiopathogenic clues. In the same way, the model of functional organization of basal ganglia circuitry gives a basis for further experimental and therapeutic research. (C) 1999 Elsevier, Paris.
引用
收藏
页码:117 / 121
页数:5
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