Pd-Catalyzed Denitrative Intramolecular C-H Arylation

被引：45

作者：

Asahara, Kitty K. ^{[1
]}

Okita, Toshimasa ^{[1
]}

Saito, Ami N. ^{[1
]}

Muto, Kei ^{[1
]}

Nakao, Yoshiaki ^{[2
]}

Yamaguchi, Junichiro ^{[1
]}

机构：

[1] Waseda Univ, Dept Appl Chem, Shinjuku Ku, 3-4-1 Ohkubo, Tokyo 1698555, Japan

[2] Kyoto Univ, Grad Sch Engn, Dept Mat Chem, Kyoto 6158510, Japan

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 12期

关键词：

BOND ACTIVATION; COUPLING REACTIONS; FUNCTIONALIZATION; DECARBONYLATION; HETEROARENES; CHLORIDES;

D O I：

10.1021/acs.orglett.9b01593

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed intramolecular C-H arylation of nitroarenes has been developed. Nitroarenes bearing tethered aryl groups at the ortho-position can be readily prepared in one step from 2-halonitroarenes by a nucleophilic aromatic substitution (SNAr). Under Pd/BrettPhos catalysis, activations of the C-NO2 bond as well as the C-H bond on arenes generated the corresponding biaryl linkage in moderate to excellent yields.

引用

页码：4721 / 4724

页数：4

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