Clinical features and brain structural changes in magnetic resonance imaging in Alzheimer's disease patients with apathy

被引：7

作者：

Yu, Shu-Yang ^{[1
]}

Zhu, Wan-Lin ^{[2
]}

Guo, Peng ^{[1
]}

Li, Shao-Wu ^{[3
]}

Liu, Ya-Ou ^{[4
]}

Lian, Teng-Hong ^{[1
]}

Ding, Du-Yu ^{[1
]}

Li, Dan-Ning ^{[1
]}

Li, Li-Xia ^{[5
]}

Liu, Li ^{[5
]}

Zhao, Hui ^{[5
]}

Zuo, Li-Jun ^{[1
]}

Hu, Yang ^{[1
]}

Yu, Qiu-Jin ^{[1
]}

Jin, Zhao ^{[1
]}

Wang, Rui-Dan ^{[1
]}

Gao, Jun-Hua ^{[1
]}

Zhu, Rong-Yan ^{[1
]}

Wang, Xiao-Min ^{[6
]}

Zhang, Wei ^{[7
,8
,9
,10
]}

机构：

[1] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100070, Peoples R China

[2] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China

[3] Beijing Neurosurg Inst, Beijing 100070, Peoples R China

[4] Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100070, Peoples R China

[5] Capital Med Univ, Beijing Tiantan Hosp, Dept Gen Internal Med, Beijing 100070, Peoples R China

[6] Capital Med Univ, Dept Physiol, Beijing 100069, Peoples R China

[7] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Ctr Cognit Neurol, Beijing 100070, Peoples R China

[8] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing 100070, Peoples R China

[9] Beijing Inst Brain Disorders, Ctr Parkinsons Dis, Beijing 100053, Peoples R China

[10] Beijing Key Lab Parkinsons Dis, Beijing 100053, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 19期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Alzheimer's disease; apathy; clinical features; brain structural changes; magnetic resonance imaging; MILD COGNITIVE IMPAIRMENT; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; NEUROPSYCHIATRIC SYMPTOMS; APOLIPOPROTEIN-E; SEGMENTATION; RELIABILITY; THICKNESS; ATROPHY; RISK;

D O I：

10.18632/aging.103705

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Background: Apathy is common in Alzheimer's disease (AD) patients. However, its relation with other clinical symptoms in AD and brain structural changes in magnetic resonance imaging is unclear. Results: Compared with AD with no apathy group, cognitive function and activities of daily living were significantly impaired and neuropsychiatric symptoms were obviously presented in AD with apathy group (P<0.05). The frequency of Apolipoprotein E genotypes was not significantly different (P>0.05). Correlation analyses and multiple linear analyses revealed that thickness of left temporal pole and volume of posterior corpus callosum were significantly and negatively correlated with Modified Apathy Estimation Scale score in AD patients (P<0.05). Conclusions: Apathy with AD is positively correlated with cognitive impairment, neuropsychiatric symptoms and poor activities of daily living. Atrophy of left temporal pole and posterior corpus callosum presented by MRI is positively related with apathy of AD. Methods: In this study, 137 AD patients were recruited and divided into AD with apathy group and AD with no apathy group according to Modified Apathy Estimation Scale score. We evaluated patients' cognitive function, neuropsychiatric symptoms and activities of daily living, detected the frequency of Apolipoprotein E genotypes and measured cortical thickness and volume by magnetic resonance imaging (MRI).

引用

页码：19083 / 19094

页数：12

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