Geographical distribution and clinical relevance of non-tuberculous mycobacteria in Croatia

被引:56
作者
Jankovic, M. [1 ]
Samarzija, M. [1 ]
Sabol, I. [2 ]
Jakopovic, M. [1 ]
Jankovic, V. Katalinic [3 ]
Zmak, L. [3 ]
Ticac, B. [4 ]
Marusic, A. [5 ]
Obrovac, M. [3 ]
van Ingen, J. [6 ]
机构
[1] Univ Zagreb, Sch Med, Univ Hosp Ctr, Dept Resp Dis, Zagreb 41001, Croatia
[2] Rudjer Boskovic Inst, Lab Mol Virol & Bacteriol, Div Mol Med, Zagreb, Croatia
[3] Croatian Natl Inst Publ Hlth, Natl Mycobacterial Reference Lab, Zagreb, Croatia
[4] Univ Rijeka, Sch Med, Dept Microbiol & Parasitol, Rijeka, Croatia
[5] Polyclin Medikol, Dept Radiol, Zagreb, Croatia
[6] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
关键词
atypical mycobacteria; epidemiological study; geographical diversity; pulmonary NTM disease; DISEASE; EPIDEMIOLOGY; PREVALENCE; FEATURES;
D O I
10.5588/ijtld.12.0843
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
SETTING: The clinical relevance of non-tuberculous mycobacteria (NTM) in Croatia is unknown. OBJECTIVE: To estimate the isolation rate of NTM, record geographical differences and assess the burden of pulmonary NTM disease in Croatia. DESIGN: Nationwide retrospective cohort study of all Croatian residents with NTM isolated by culture in the period from 2006 to 2010. Microbiological criteria of the American Thoracic Society were used to establish a laboratory-based case definition of possible and probable NTM disease. RESULTS: Of 1187 individuals with pulmonary NTM isolates, 8.6% met the possible and 5.5% met the probable disease criteria. We estimated an annual incidence of probable pulmonary NTM disease of 0.23 per 100 000 population. This estimated annual incidence was 0.35/100 000 in the coastal region and 0.17/100 000 in the continental region. Species distribution differed between coastal and continental Croatia. NTM isolation frequency increased over the study period. CONCLUSION: Geography plays an important role in NTM species distribution and possible disease. The overall burden of NTM pulmonary disease in Croatia is still low compared to that of tuberculosis, but it is higher in the coastal region compared to the continental region.
引用
收藏
页码:836 / 841
页数:6
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