Cytotoxic effects of palladium(II) and platinum(II) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(4-methyl) pentanoic acid on human colon cancer cell lines

被引：0
作者：
Volarevic, V. [1 ]
Vujic, J. M. [2 ]
Milovanovic, M. [1 ]
Kanjevac, T. [1 ]
Volarevic, A. [1 ]
Trifunovic, S. R. [3 ]
Arsenijevic, N. [1 ]
机构：
[1] Univ Kragujevac, Fac Med Sci, Ctr Mol Med & Stem Cell Res, Kragujevac, Serbia
[2] Univ Kragujevac, Fac Agron, Cacak, Serbia
[3] Univ Kragujevac, Fac Sci, Dept Chem, Kragujevac, Serbia
来源：
JOURNAL OF BUON | 2013年 / 18卷 / 01期
关键词：
cytotoxic effects; human colon cancer cell lines; palladium(II) complexes; platinum(II) complexes; VITRO ANTITUMORAL ACTIVITY; IN-VITRO; LIGANDS; CISPLATIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Purpose: As novel therapeutic agents relevant to colon cancer therapy are explored continuously, we tested 4 R(2)edda-type ligand precursors O,O'-dialkyl esters of (S,S) -ethylenediamine-N,N'-di-2-(4-methyl)pentanoic acid (L1 center dot 2HCl-L4 center dot 2HCl) and corresponding palladium(II) and platinum(II) complexes against the human colon cancer cell lines CaCo-2, SW480 and HCT116. Methods: The effects of the tested compounds on cell viability were determined using MTT colorimetric technique. Results: Analysis of cancer cell viability showed that all tested ligand precursors, palladium(II) and platinum(II) complexes were cytotoxic on human colon cancer cells in dose-dependent manner. The cytotoxic activity of all palladium(II) and platinum(II) complexes toward selected cancer cells was significantly higher in comparison to cisplatin. Among the tested platinum(II) and palladium(II) complexes the lowest activity was observed for the compounds with the shortest ester chain and the highest activity was noted for palladium(II) complex No.2 with the n-Pr group in ester chain and for platinum(II) complex No.7 with the n-Bu group in ester chain. Conclusion: Palladium(II) complex No.2 and platinum(II) complex No.7 seem to be good candidates for future pharmacological evaluation in the field of colon cancer research and treatment.
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页码：131 / 137
页数：7
相关论文
共 21 条
[11]   The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo [J].
Kuribayashi, Kageaki ;
Finnberg, Niklas ;
Jeffers, John R. ;
Zambetti, Gerard P. ;
El-Deiry, Wafik S. .
CELL CYCLE, 2011, 10 (14) :2380-2389
[12]   Synthesis and in vitro Anticancer Activity of Octahedral Platinum(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N′-Diacetate-Type Ligands [J].
Lazic, Jelena M. ;
Vucicevic, Ljubica ;
Grguric-Sipka, Sanja ;
Janjetovic, Kristina ;
Kaluderovic, Goran N. ;
Misirkic, Maja ;
Gruden-Pavlovic, Maja ;
Popadic, Dusan ;
Paschke, Reinhard ;
Trajkovic, Vladimir ;
Sabo, Tibor J. .
CHEMMEDCHEM, 2010, 5 (06) :881-889
[13]   RAPID COLORIMETRIC ASSAY FOR CELLULAR GROWTH AND SURVIVAL - APPLICATION TO PROLIFERATION AND CYTO-TOXICITY ASSAYS [J].
MOSMANN, T .
JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :55-63
[14]   Molecular mechanisms of resistance and toxicity associated with platinating agents [J].
Rabik, Cara A. ;
Dolan, M. Eileen .
CANCER TREATMENT REVIEWS, 2007, 33 (01) :9-23
[15]   Complex compounds of platinum(IV) and O,O-dialkyl-ethylenediamine-N,N′-di-3-propanoate ligands.: A structural evidence for geometry of hydrolytic product of some esters [J].
Sabo, TJ ;
Kaluderovic, GN ;
Grguric-Sipka, SR ;
Heinemann, FW ;
Trifunovic, SR .
INORGANIC CHEMISTRY COMMUNICATIONS, 2004, 7 (02) :241-244
[16]  
Susman S, 2012, J BUON, V17, P230
[17]   Preclinical in vitro evaluation of hematotoxicity of the cisplatin-procaine complex DPR [J].
Viale, M ;
Minetti, S ;
Ottone, M ;
Lerza, R ;
Parodi, B ;
Pannacciulli, L .
ANTI-CANCER DRUGS, 2003, 14 (02) :163-166
[18]   Stereospecific ligands and their complexes. Part VII. Synthesis, characterization and in vitro antitumoral activity of platinum(II) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(4-methyl)pentanoic acid [J].
Vujic, Jelena M. ;
Kaluderovic, Goran N. ;
Milovanovic, Marija ;
Zmejkovski, Bojana B. ;
Volarevic, Vladislav ;
Zivic, Danijela ;
Durdevic, Predrag ;
Arsenijevic, Nebojsa ;
Trifunovic, Srecko R. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 46 (09) :4559-4565
[19]   Palladium(II) complexes with R2edda derived ligands. Part IV. O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells [J].
Vujic, Jelena M. ;
Cvijovic, Milica ;
Kaluderovic, Goran N. ;
Milovanovic, Marija ;
Zmejkovski, Bojana B. ;
Volarevic, Vladislav ;
Arsenijevic, Nebojsa ;
Sabo, Tibor J. ;
Trifunovic, Srecko R. .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (09) :3601-3606
[20]   Infrared spectral signatures of CDCP1-induced effects in colon carcinoma cells [J].
Yousef, Ibraheem ;
Breard, Jacqueline ;
SidAhmed-Adrar, Nazha ;
Maamer-Azzabi, Aida ;
Marchal, Celine ;
Dumas, Paul ;
Le Naour, Francois .
ANALYST, 2011, 136 (24) :5162-5168
123