SYNTHESIS, CHEMICAL PROPERTIES, AND BIOLOGICAL EVALUATIONS OF SOME TWIN-DRUG TYPE C2-SYMMETRICAL DERIVATIVES

被引：8

作者：

Fujisaki, Fumiko ^{[1
]}

Usami, Haruka ^{[1
]}

Nakashima, Saya ^{[1
]}

Nishida, Sho ^{[1
]}

Fujioka, Toshihiro ^{[1
]}

Kashige, Nobuhiro ^{[1
]}

Miake, Fumio ^{[1
]}

Sumoto, Kunihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Jonan Ku, Fukuoka 8140180, Japan

来源：

HETEROCYCLES | 2013年 / 87卷 / 03期

关键词：

Aminoguanidine; Oxazolidinone; Symmetrical Molecule; alpha-Glucosidase Inhibition Activity; Antibacterial Activity; SYMMETRY; MEMBER; ROUTE;

D O I：

10.3987/COM-12-12654

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe the synthesis and chemical properties of newly designed C-2-symmetrical twin-drug type aminoguanidines or 4-aminomethyloxazolidinone derivatives (4-7) in which a long chain alkyl group [-(CH2)(10)-] was used as a linker. Synthesis of some triplet-drug type symmetrical oxazolidinones (8) is also described. Among the tested compounds, the aminoguanidine derivative 4a showed the highest alpha-glucosidase inhibition activity (IC50 = 76.3 mu mol/L).

引用

页码：665 / 675

页数：11

共 19 条

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