Guarding against Collateral Damage during Chromatin Transactions

被引：13
作者：
Altmeyer, Matthias [1 ]
Lukas, Jiri [1 ]
机构：
[1] Univ Copenhagen, Chromosome Stabil & Dynam Grp, Dept Dis Biol, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark
来源：
CELL | 2013年 / 153卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
UBIQUITIN-DEPENDENT RESPONSE; DNA-DAMAGE; LIMITS; RNF169; RIF1;
D O I：
10.1016/j.cell.2013.05.044
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Signal amplifications are vital for chromatin function, yet they also bear the risk of transforming into unrestrained, self-escalating, and potentially harmful responses. Examples of inbuilt limitations are emerging, revealing how chromatin transactions are confined within physiological boundaries.
引用
收藏
页码：1431 / 1434
页数：4
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