DNA methylation in human diseases

被引：291

作者：

Jin, Zelin ^{[1
]}

Liu, Yun ^{[1
]}

机构：

[1] Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Minist Educ,Key Lab Metab & Mol Med, Shanghai, Peoples R China

来源：

GENES & DISEASES | 2018年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DNA Methylation; Epigenetic epidemiologic studies; Epigenetics; EWAS; Human diseases; EPIGENOME-WIDE ASSOCIATION; CELL-FREE DNA; RHEUMATOID-ARTHRITIS; 5-HYDROXYMETHYLCYTOSINE SIGNATURES; EPIGENETIC REGULATION; CANCER PROGRESSION; MATERNAL SMOKING; GENE-EXPRESSION; IGF2; GENE; BLOOD;

D O I：

10.1016/j.gendis.2018.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Even though the importance of epigenetics was first recognized in light of its role in tissue development, an increasing amount of evidence has shown that it also plays an important role in the development and progression of many common diseases. We discuss some recent findings on one representative epigenetic modification, DNA methylation, in some common diseases. While many new risk factors have been identified through the population-based epigenetic epidemiologic studies on the role of epigenetics in common diseases, this relatively new field still faces many unique challenges. Here, we describe those promises and unique challenges of epigenetic epidemiological studies and propose some potential solutions. Copyright (C) 2018, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：1 / 8

页数：8

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