Notch signaling during cell fate determination in the inner ear

被引：76
作者：
Kiernan, Amy E. [1 ,2 ]
机构：
[1] Univ Rochester, Dept Ophthalmol, Rochester, NY 14642 USA
[2] Univ Rochester, Dept Biomed Genet, Rochester, NY 14642 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2013年 / 24卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Notch; Inner ear; Hair cell; Cochlea; Otic vesicle; Jagged; SENSORY ORGAN DEVELOPMENT; HAIR-CELLS; LATERAL INHIBITION; MAMMALIAN COCHLEA; STEM-CELLS; EMBRYONIC-DEVELOPMENT; SUPPORTING CELLS; CIS-INTERACTIONS; CROSS-REGULATION; WING DEVELOPMENT;
D O I：
10.1016/j.semcdb.2013.04.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In the inner ear, Notch signaling has been proposed to specify the sensory regions, as well as regulate the differentiation of hair cells and supporting cell within those regions. In addition, Notch plays an important role in otic neurogenesis, by determining which cells differentiate as neurons, sensory cells and non-sensory cells. Here, I review the evidence for the complex and myriad roles Notch participates in during inner ear development. A particular challenge for those studying ear development and Notch is to decipher how activation of a single pathway can lead to different outcomes within the ear, which may include changes in the intrinsic properties of the cell, Notch modulation, and potential non-canonical pathways. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：470 / 479
页数：10
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