Regulating the acrosome reaction

被引：109

作者：

Florman, Harvey M. ^{[1
]}

Jungnickel, Melissa K. ^{[1
]}

Sutton, Keith A. ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01655 USA

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2008年 / 52卷 / 5-6期

关键词：

acrosome reaction; signal transduction calcium channel; TRPC channel; PI3; kinase;

D O I：

10.1387/ijdb.082696hf

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction. Here, we discuss the mechanism by which ZP3 generates Ca2+ entry, as well as the upstream events leading to this influx and downstream processes that couple it with exocytosis.

引用

页码：503 / 510

页数：8

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