Efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones catalyzed by titanium silicon oxide nanopowder in aqueous media

被引：25

作者：

Mekala, Ramamohan ^{[1
,2
]}

Madhubabu, M. V. ^{[1
]}

Dhanunjaya, G. ^{[1
]}

Regati, Sridhar ^{[1
]}

Chandrasekhar, K. B. ^{[2
]}

Sarva, Jayaprakash ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Technol Dev Ctr, Custom Pharmaceut Serv, Bollaram Rd, Hyderabad, Telangana, India

[2] Jawaharlal Nehru Technol Univ Anantapur, Dept Chem, Ananthapuramu, Andhra Pradesh, India

来源：

SYNTHETIC COMMUNICATIONS | 2017年 / 47卷 / 02期

关键词：

Green chemistry; nanopowder; nitrogen heterocycles; quinazolinones; reusable catalyst; ONE-POT; WATER; MILD;

D O I：

10.1080/00397911.2016.1254801

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives is accomplished in aqueous media by a three-component reaction of isatoic anhydride, primary amines or ammonium acetate, and aldehydes catalyzed by titanium silicon oxide nanopowder. A variety of 2,3-dihydroquinazolin-4(1H)-one derivatives were synthesized using this methodology in good to excellent yields. The catalyst was recovered and recycled up to four times without significant loss in the catalytic activity. [GRAPHICS] .

引用

页码：121 / 130

页数：10

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