Maternal smoking during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis

被引：17
作者：
Yu, Chengjun [1 ,2 ]
Wei, Yi [1 ,2 ]
Tang, Xiangliang [1 ,2 ]
Liu, Bin [1 ,3 ]
Shen, Lianju [1 ,4 ]
Long, Chunlan [1 ,5 ]
Lin, Tao [1 ,3 ]
He, Dawei [1 ,3 ]
Wu, Shengde [1 ,2 ,3 ]
Wei, Guanghui [1 ,2 ,3 ]
机构：
[1] Chongqing Med Univ, Childrens Hosp, Dept Urol, Room 806,Kejiao Bldg,6 Bldg,136 2nd Zhongshan Rd, Chongqing 400014, Peoples R China
[2] Chongqing Key Lab Children Urogenital Dev & Tissu, Chongqing, Peoples R China
[3] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China
[4] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China
[5] Chongqing Key Lab Pediat Chongqing, Chongqing, Peoples R China
来源：
EUROPEAN JOURNAL OF PEDIATRICS | 2019年 / 178卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Cryptorchidism; Maternal smoking; Meta-analysis; ENDOCRINE-DISRUPTING CHEMICALS; TESTICULAR DESCENT; HYPOSPADIAS; ASSOCIATION; EXPOSURE; BIRTH; DELIVERY; COHORT; BOYS; AGE;
D O I：
10.1007/s00431-018-3293-9
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The risk factors for undescended testes in male infants and the underlying pathogenesis still remain unclear. The aim of this study is to identify the relationship between maternal smoking during pregnancy and risk of cryptorchidism. A systematic review was conducted using appropriate search terms to identify articles pertaining to maternal smoking during pregnancy and risk of cryptorchidism. Entries up to December 23, 2017 were taken into consideration, without any language or regional restriction. The crude ORs and their 95% CIs were computed by using the fixed-effect model. Twenty studies involving 111,712 infants were included in our meta-analysis. The risk of having a male infant with cryptorchidism was significantly different between mothers who smoked during pregnancy and those who did not (pooled crude OR 1.18, 95% confidence interval [CI] 1.12-1.24, p<0.00001).Conclusion: Our findings suggest that smoking during pregnancy increased the risk of cryptorchidism by 1.18 times. Further investigations that are well-designed, multicentric studies measuring variables, such as the number of cigarettes smoked in a day and the stage of pregnancy during which the mothers smoked, are necessary to precisely determine the relationship between maternal smoking and risk of cryptorchidism.
引用
收藏
页码：287 / 297
页数：11
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