Alpinetin/hydroxypropyl-β-cyclodextrin host-guest system: Preparation, characterization, inclusion mode, solubilization and stability

被引：65
作者：
Ma, Shui-Xian [2 ,3 ]
Chen, Wen [1 ]
Yang, Xiao-Dong [1 ]
Zhang, Na [2 ]
Wang, Shao-Jie [2 ]
Liu, Lin [4 ]
Yang, Li-Juan [2 ,3 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
[2] Yunnan Univ Nat, Key Lab Ethn Med Resource Chem State Ethn Affairs, Kunming 650500, Peoples R China
[3] Yunnan Univ Nat, Engn Lab Polylact Acid Based Funct Mat Yunnan, Kunming 650500, Peoples R China
[4] Yunnan Reascend Tobacco Technol Grp Co LTD, Kunming 650106, Peoples R China
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2012年 / 67-68卷
关键词：
Alpinetin; Hydroxypropyl-beta-cyclodextrin; Inclusion complex; Solubilization; Stability; BRIDGED BIS(BETA-CYCLODEXTRIN)S; BINDING; COMPLEXES; ALPINETIN; CARDAMONIN; CARRIERS;
D O I：
10.1016/j.jpba.2012.04.038
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The inclusion complexation behavior, characterization and binding ability of alpinetin with hydroxypropyl-beta-cyclodextrin (HP beta CD) has been investigated in both solution and the solid state by means of UV-vis spectroscopy, FT-IR, H-1 and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and stability of alpinetin were obviously increased in the inclusion complex with HP beta CD. This satisfactory water solubility and high stability of the alpinetin/HP beta CD complex will be potentially useful for its application as herbal medicine or healthcare products. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：193 / 200
页数：8
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