Biocompatible and biodegradable polymersomes as delivery vehicles in biomedical applications

被引：96

作者：

Liu, Gong-Yan ^{[1
]}

Chen, Chao-Jian ^{[1
]}

Ji, Jian ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China

来源：

SOFT MATTER | 2012年 / 8卷 / 34期

关键词：

GLYCOL)-POLY(D; L-LACTIDE); BLOCK-COPOLYMERS; DRUG-DELIVERY; IN-VITRO; BIOMIMETIC POLYMERSOMES; INTRACELLULAR DRUG; TRIGGERED RELEASE; BRAIN DELIVERY; VESICLES; PH; MICELLES;

D O I：

10.1039/c2sm25721a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Biocompatible and biodegradable polymersomes are commonly self-assembled from amphiphilic diblock copolymers composed of hydrophilic poly(ethylene glycol) (PEG) or poly-(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segments and hydrophobic polyester blocks, such as poly(lactic acid) (PLA) or poly(epsilon-caprolactone) (PCL). Such polymersomes have emerged as promising delivery vehicles for pharmaceutical applications. Presented in this review are summaries of recent developments of biocompatible and biodegradable polymersomes, including self-assembly, encapsulation of various therapeutics, pH-induced hydrolysis for controlled release as well as their functionalization and intelligent design.

引用

页码：8811 / 8821

页数：11

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