Novel Aminomethyl Derivatives of 4-Methyl-2-prenylphenol: Synthesis and Antioxidant Properties

被引：10

作者：

Buravlev, Evgeny V. ^{[1
]}

Fedorova, Irina V. ^{[1
]}

Shevchenko, Oksana G. ^{[2
]}

Kutchin, Aleksandr V. ^{[1
]}

机构：

[1] Russian Acad Sci, Ural Branch, Inst Chem, Komi Sci Ctr, 48 Pervomayskaya St, Syktyvkar 167000, Komi Republic, Russia

[2] Russian Acad Sci, Ural Branch, Inst Biol, Komi Sci Ctr, 28 Kommunisticheskaya St, Syktyvkar 167982, Komi Republic, Russia

来源：

CHEMISTRY & BIODIVERSITY | 2019年 / 16卷 / 03期

关键词：

alkylation; Mannich bases; antioxidant activity; red blood cells; oxidative hemolysis; synthesis design; MEMBRANE-PROTECTIVE ACTIVITY; BIOLOGICAL EVALUATION; MANNICH-BASES; IN-VITRO; XANTHONES; DAMAGE;

D O I：

10.1002/cbdv.201800637

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

4-Methyl-2-prenylphenol (1) was synthesized from para-cresol and prenol, natural alcohol under the conditions of heterogeneous catalysis. A series of nine new aminomethyl derivatives with secondary and tertiary amino groups were obtained on the basis of compound 1. A comparative evaluation of their antioxidant properties was carried out using in vitro models. It was established that Mannich base with octylaminomethyl group has radical-scavenging activity, high Fe2+-chelation ability as well as the ability to inhibit oxidative hemolysis of red blood cells.

引用

页数：10

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